Condition

Advanced Malignant Solid Neoplasm clinical trials and research

• 23Clinical trials
• 2Countries

Newest Advanced Malignant Solid Neoplasm clinical trials

All recruiting trials (23)

• Morning versus afternoon immunotherapy for advanced or metastatic solid tumors

  This trial tests whether giving standard immune checkpoint inhibitor therapy in the morning versus the afternoon changes outcomes for adults with advanced or metastatic solid tumors.

  Recruiting Phase 4 OHSU Knight Cancer Institute · Portland, Oregon · NCT07405086

• TR-002 (Nadofaragene Firadenovec) given by IV for adults with advanced unresectable or metastatic solid tumors and refractory metastatic pancreatic adenocarcinoma

  This Phase 1 trial tests whether weekly intravenous TR-002 is safe and what dose is best for adults with advanced unresectable or metastatic solid tumors or refractory metastatic pancreatic cancer.

  Recruiting Phase 1 University of California, Davis · Sacramento, California · NCT07189195

• Early advance care planning education for young adults with advanced solid tumors or high-grade brain tumors

  This project will test whether short educational tools help adolescents and young adults (diagnosed at 18–39) with advanced solid tumors or high-grade brain tumors start advance care planning earlier.

  Recruiting Mayo Clinic · Scottsdale, Arizona · NCT07174661

• Telephone coaching to help people with advanced cancer and their support person plan for end-of-life care

  This program tests whether two phone coaching sessions help people with advanced cancer and their support person have end-of-life conversations and complete advance directives.

  Recruiting at 3 sites Fred Hutchinson Cancer Center · Everett, Washington and 2 other locations · NCT07141407

• Using siltuximab to prevent severe side effects during cancer treatment

  This study is testing if the drug siltuximab can help prevent severe side effects in cancer patients who are getting immune therapy again.

  Recruiting Phase 2 Ohio State University Comprehensive Cancer Center · Columbus, Ohio · NCT06470971

• Combining axatilimab, retifanlimab, and paclitaxel for advanced solid tumors

  This study is testing a new combination of three medications to see if they can help people with advanced solid tumors feel better and improve their treatment outcomes.

  Recruiting Phase 1/2 OHSU Knight Cancer Institute · Portland, Oregon · NCT06320405

• Personalized treatment for advanced solid tumors using antibody-drug conjugates

  This study is testing if personalized treatments using special antibody-drug combinations can help people with advanced solid tumors that have certain proteins.

  Recruiting at 29 sites Phase 2 National Cancer Institute (NCI) · Duarte, California and 28 other locations · NCT06311214

• Evaluating TAK-243 for advanced cancer treatment

  This study is testing a new drug called TAK-243 to see if it can safely help people with advanced cancer by looking at how it affects their tumors and overall health.

  Recruiting Phase 1 National Cancer Institute (NCI) · Bethesda, Maryland · NCT06223542

• At-home cancer treatment versus clinic-based treatment for advanced cancer patients

  This study tests whether giving cancer treatment at home is better for comfort and satisfaction compared to getting it at a clinic for people with advanced cancer.

  Recruiting at 2 sites Phase 2 Mayo Clinic · Jacksonville, Florida and 1 other locations · NCT05969860

• CPI-613 combined with hydroxychloroquine and chemotherapy for advanced solid tumors

  This study is testing a new combination of treatments, including CPI-613 and hydroxychloroquine, to see if it can help people with advanced solid tumors that haven't improved with other chemotherapy.

  Recruiting Phase 2 Northwestern University · Chicago, Illinois · NCT05733000

• Using olanzapine to help cancer patients regain appetite and manage weight loss

  This study is testing if the medication olanzapine can help cancer patients who are losing weight and have a poor appetite feel better and gain weight while they are receiving treatment.

  Recruiting Phase 2 OHSU Knight Cancer Institute · Portland, Oregon · NCT05705492

• Testing CBX-12 for advanced solid cancers

  This study is testing a new drug called CBX-12 to see if it can help people with advanced solid tumors by killing cancer cells more effectively than current treatments.

  Recruiting Phase 1 National Cancer Institute (NCI) · Bethesda, Maryland · NCT05691517

• Combining Temozolomide and M1774 to Treat Advanced Cancer

  This study is testing a combination of two cancer drugs, temozolomide and M1774, to see if they can help people with advanced metastatic cancers feel better and improve their treatment outcomes.

  Recruiting at 15 sites Phase 1/2 National Cancer Institute (NCI) · Irvine, California and 22 other locations · NCT05691491

• Combining two anti-cancer drugs for advanced solid tumors

  This study is testing if a combination of two anti-cancer drugs can be safely used to help people with advanced solid tumors that have spread.

  Recruiting at 6 sites Phase 1 National Cancer Institute (NCI) · Bethesda, Maryland and 6 other locations · NCT05687136

• Targeted therapy for advanced solid tumors based on genetic testing

  This study is testing whether matching patients with advanced solid tumors to specific treatments based on their genetic makeup can improve their outcomes when standard options have failed.

  Recruiting at 437 sites Phase 2 National Cancer Institute (NCI) · Birmingham, Alabama and 483 other locations · NCT05564377

• Combining ZEN003694 and Binimetinib for Advanced Solid Tumors with RAS Alterations

  This study is testing a combination of two cancer drugs, ZEN003694 and binimetinib, to see if they can help people with advanced solid tumors that have RAS changes.

  Recruiting Phase 1 National Cancer Institute (NCI) · Boston, Massachusetts and 3 other locations · NCT05111561

• Testing a new drug combination for advanced cancer and lymphoma

  This study is testing a new combination of two drugs to see if it can help people with advanced cancer and lymphoma feel better and live longer.

  Recruiting at 3 sites Phase 1/2 National Cancer Institute (NCI) · New Haven, Connecticut and 2 other locations · NCT05053971

• Treatment of advanced solid tumors with IACS-6274 and other medications

  This study is testing a new drug called IACS-6274, alone and with other medications, to see how well it can help people with advanced solid tumors and what the safest dose is.

  Recruiting Phase 1 M.D. Anderson Cancer Center · Houston, Texas · NCT05039801

• Combining NBTXR3 with radiation and immunotherapy for advanced solid tumors

  This study is testing a new treatment using NBTXR3 along with radiation and immunotherapy to see if it helps people with advanced solid tumors that have spread to the lungs or liver.

  Recruiting Phase 1/2 M.D. Anderson Cancer Center · Houston, Texas · NCT05039632

• Improving palliative care for advanced cancer patients in underserved areas

  This study is testing a new way to improve palliative care for advanced cancer patients and their caregivers in underserved areas of Africa and India by helping local healthcare providers learn how to offer better support.

  Recruiting Phase 2 M.D. Anderson Cancer Center · Houston, Texas · NCT04984551

• Combining talazoparib with palbociclib, axitinib, or crizotinib for advanced solid tumors

  This study is testing a new combination of drugs for people with advanced solid tumors to see which mix works best and is safest to use.

  Recruiting Phase 1 M.D. Anderson Cancer Center · Houston, Texas · NCT04693468

• Treatment of advanced cancers with RSC-1255

  This study is testing a new oral drug called RSC-1255 to see if it can help adults with advanced cancers that haven't responded to other treatments.

  Recruiting at 3 sites Phase 1 RasCal Therapeutics, Inc. · Los Angeles, California and 2 other locations · NCT04678648

• Combining trifluridine/tipiracil with talazoparib for advanced colorectal or gastroesophageal cancer

  This study is testing a new combination of two cancer drugs to see if they can safely help people with advanced colorectal or gastroesophageal cancer.

  Recruiting Phase 1 Roswell Park Cancer Institute · Buffalo, New York · NCT04511039

Related topics

Quick answers

How many Advanced Malignant Solid Neoplasm clinical trials are recruiting right now?

23, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 2 countries. The most sites are in United States (23 trials), Puerto Rico (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 1: 9, Phase 2: 7, Phase 1/2: 4, Phase 4: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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