Examining the link between physical activity and survival in advanced cancer patients

Inclusion Criteria:

* Diagnosis of any stage I - IV colorectal cancer or recurrent colorectal cancer (Arm 1)
* Able to speak, read, and write in English (Pre-pilot phase, Arms 1-4)
* Able to provide informed consent (Pre-pilot phase, Arms 1-4, PCS study)
* Lives in the Houston area (Harris county or a contiguous county) (Pre-pilot phase)
* Eastern Cooperative Oncology Group (ECOG) status of 0 - 2, or self-reports being up and about more than 50% of waking hours and able to provide self-care (Arm 1)
* Diagnosis of any of the following cancers: stage 1-4b oropharyngeal, hypopharyngeal, nasopharyngeal, salivary gland or oral cavity; stage 3-4b laryngeal; any unknown primary head and neck cancer with cervical metastasis that will be addressed with treatment to bilateral necks and mucosa; or other head and neck cancers medically approved by one of our Radiation Oncology collaborating medical doctors (MDs) (Arms 2 and 3)
* History of any cancer, other than non-melanoma skin cancer (Arm 4)
* Admitted to being a current smoker or recent quitter upon admission to MD Anderson Cancer Center (MDACC) (Arm 4)
* Has a valid home address and functioning home telephone number (Arm 4)
* Lives in the Houston or surrounding area, or resides in this same area during the time period that coincides with this study (Arms 1-4)
* Patients who will undergo curative pancreatectomy for pancreatic adenocarcinoma, pancreatic neuroendocrine tumors, or pancreatic cysts (malignant or benign) (PCS study)
* Fluent in English (PCS study)
* Must have telephone access and agree to engage with research personnel using telephone (PCS study)
* Diagnosis of a metastatic or locally unresectable solid tumor (TAPS study)
* Fluent in English (TAPS study)
* Age 18 years or older (TAPS study)
* ECOG performance status score between 0-3 (TAPS study)

Exclusion Criteria:

* Major surgery in the past 8 weeks (Arms 1 and 4)
* Self-reports hypertension that is not being monitored by a physician and is not being managed with either medication, observation, or lifestyle change (Pre-pilot phase, Arms 1-3)
* Overt cognitive difficulty demonstrated by not being clearly oriented to time or person or place (Arms 1-4)
* Orthopedic, neurologic, or musculoskeletal disability that would interfere with the functional task of standing on a weight scale (Pre-pilot phase, Arm 2)
* Not currently receiving radiation treatment for a cancer listed in the arm-specific inclusion criteria (Arms 2 and 3)
* Zubrod performance status \> 2, or self-reports either not being up and about more than 50% of waking hours or unable to provide self-care (Arms 2 and 3)
* Currently receiving treatment for a cancer other than those listed in the arm-specific inclusion criteria (exception: the study does not exclude those receiving treatment for non-melanoma skin cancer) (Arms 2 and 3)
* History of current oropharyngeal dysphagia unrelated to cancer diagnosis (e.g. dysphagia due to underlying neurogenic disorder) (Arm 3 only)
* Active substance use disorder (diagnosed or strongly suspected) (Arm 4)
* Currently enrolled in protocol 2014-0712 (PCS study)
* No home access to internet (PCS study)
* No home WiFi connection (PCS study)
* During clinician's pre-surgical evaluation, presents with high risk for non-therapeutic resection related to cancer diagnosis (PCS study)
* Underlying unstable cardiac or pulmonary disease or symptomatic cardiac disease (New York Heart Association functional class III or IV) (PCS study)
* Recent fracture or acute musculoskeletal injury that precludes the ability to fully bear weight on all 4 limbs in order to participate in an exercise intervention (PCS study)
* Poorly-controlled pain with a self-reported pain score of 7/10 at the time of enrollment (PCS study)
* Myopathic or rheumatologic disease that impacts physical function (PCS study)
* Has a pacemaker or other internal medical device, or reports being pregnant (PCS study)
* Currently enrolled in protocol 2017-0198 (PCS study)
* Demonstration of overt cognitive difficulty as demonstrated by not being clearly oriented to time or person or place (TAPS study)