Clinical trial Recruiting at 1 site Observational Ages 18 and up

Analyzing genetic mutations in cancer patients' blood and saliva

Official title: An Investigation of the Role of Germ-Line Mutations in Cancer Predisposition, Tumor Biology, and Response to Treatment

Run by Jonsson Comprehensive Cancer Center · NCT02280161 · Data updated 2026-11-12

This study is testing whether looking at genetic changes in blood and saliva from cancer patients can help us understand their cancer risk and how well they respond to treatments.

More Malignant Neoplasm trials

Quick facts

Study typeObservational
Ages18 Years and up
SexAll
Enrollment2000 (estimated)
SponsorJonsson Comprehensive Cancer Center
Academic / other
Locations1 site (Los Angeles, California)
StatusRecruiting
StartedSeptember 16, 2014
Main results expectedSeptember 16, 2027
Study endsSeptember 16, 2028
Registry record updatedOctober 20, 2026
Trial IDNCT02280161 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates include individuals with a confirmed diagnosis of cancer who are willing to provide blood and saliva samples.

Probably not a fit

Patients whose cancer cannot be confirmed or who refuse to sign informed consent may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This research focuses on collecting and analyzing germ-line DNA and nucleic acids from blood and saliva samples of cancer patients. The primary aim is to identify new germ-line mutations that may influence cancer predisposition and treatment responses. Additionally, the study investigates how these mutations correlate with cancer outcomes and the expression of related biological markers. Patients will provide samples 1-3 times, and they will be followed for five years to assess the long-term implications of these genetic factors.

Why it matters

Potential benefit: If successful, this study could enhance understanding of genetic factors in cancer, leading to improved risk assessment and personalized treatment strategies.

How similar studies have gone: Other studies have shown promise in identifying genetic mutations related to cancer predisposition, suggesting that this approach could yield valuable insights.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Pathologically or clinical confirmed tissue diagnosis of a cancer
* Ability to understand and the willingness to sign a written informed consent

Exclusion Criteria:

* Patients will be excluded if their cancer cannot be confirmed
* Refusal to sign the informed consent

Where it's running

  • Jonsson Comprehensive Cancer Center
    Los Angeles, California, United States
    Recruiting

Study contacts

  • Principal investigator: Joanne Weidhaas — Jonsson Comprehensive Cancer Center

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

  • MK-2010 with Sac-TMT in advanced solid tumors

    This study tests MK-2010 combined with sacituzumab tirumotecan (sac-TMT) to see if it can help people with advanced solid tumors.

    Recruiting at 4 sites Phase 2 Merck Sharp & Dohme LLC · San Antonio, Texas and 3 other locations · NCT07785609

  • Belzutifan in adolescents with solid tumors

    This study tests belzutifan in teenagers whose solid tumors can't be removed by surgery or have spread.

    Recruiting at 10 sites Phase 2 Merck Sharp & Dohme LLC · Iowa City, Iowa and 9 other locations · NCT07700758

  • Ifinatamab Deruxtecan in kids with relapsed or refractory solid cancers

    This study tests whether I-DXd can help children whose solid tumors have come back or not responded to previous treatments.

    Recruiting at 35 sites Phase 1/2 Merck Sharp & Dohme LLC · Los Angeles, California and 34 other locations · NCT07630974

  • MK-4884 safety in advanced solid tumors

    This early-phase study tests different doses of MK-4884 to see if it is safe and tolerable for adults with certain advanced solid cancers.

    Recruiting at 10 sites Phase 1 Merck Sharp & Dohme LLC · St Louis, Missouri and 9 other locations · NCT07600749

  • PET scan targeting CDH3 for lung tumors

    This will test whether a new PET imaging agent called 68Ga-TOI-1 that targets CDH3 can better detect and stage lung tumors and help tell malignant from benign pulmonary nodules in adults with suspected or confirmed non-small cell lung cancer.

    Recruiting Peking University People's Hospital · Beijing, Beijing Municipality · NCT07487883

  • Dabrafenib and trametinib for rare cancers with BRAF V600 mutations

    This arm tests whether dabrafenib and trametinib can help adults, children, and teens with cancers that have a BRAF V600 mutation.

    Recruiting at 15 sites Phase 2/3 Cancer Research UK · Belfast and 26 other locations · NCT07440290

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.