Analyzing genetic mutations in cancer patients' blood and saliva
Official title: An Investigation of the Role of Germ-Line Mutations in Cancer Predisposition, Tumor Biology, and Response to Treatment
Run by Jonsson Comprehensive Cancer Center · NCT02280161 · Data updated 2026-11-12
This study is testing whether looking at genetic changes in blood and saliva from cancer patients can help us understand their cancer risk and how well they respond to treatments.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 2000 (estimated) |
| Sponsor | Jonsson Comprehensive Cancer Center Academic / other |
| Locations | 1 site (Los Angeles, California) |
| Status | Recruiting |
| Started | September 16, 2014 |
| Main results expected | September 16, 2027 |
| Study ends | September 16, 2028 |
| Registry record updated | October 20, 2026 |
| Trial ID | NCT02280161 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates include individuals with a confirmed diagnosis of cancer who are willing to provide blood and saliva samples.
✕Probably not a fit
Patients whose cancer cannot be confirmed or who refuse to sign informed consent may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This research focuses on collecting and analyzing germ-line DNA and nucleic acids from blood and saliva samples of cancer patients. The primary aim is to identify new germ-line mutations that may influence cancer predisposition and treatment responses. Additionally, the study investigates how these mutations correlate with cancer outcomes and the expression of related biological markers. Patients will provide samples 1-3 times, and they will be followed for five years to assess the long-term implications of these genetic factors.
Why it matters
Potential benefit: If successful, this study could enhance understanding of genetic factors in cancer, leading to improved risk assessment and personalized treatment strategies.
How similar studies have gone: Other studies have shown promise in identifying genetic mutations related to cancer predisposition, suggesting that this approach could yield valuable insights.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Pathologically or clinical confirmed tissue diagnosis of a cancer * Ability to understand and the willingness to sign a written informed consent Exclusion Criteria: * Patients will be excluded if their cancer cannot be confirmed * Refusal to sign the informed consent
Where it's running
-
Jonsson Comprehensive Cancer Center
Los Angeles, California, United States Recruiting
Study contacts
- Principal investigator: Joanne Weidhaas — Jonsson Comprehensive Cancer Center
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.