Condition

Lyme Disease clinical trials and research

• 10Clinical trials
• 65NIH research projects
• 4Countries

Newest Lyme Disease clinical trials

All recruiting trials (10)

• Fifth dose of the 6‑valent OspA Lyme vaccine (VLA15)

  This test gives a fifth dose of the VLA15 Lyme vaccine to people age 7 and older who already got four doses to see if it is safe and boosts immune protection.

  Recruiting at 12 sites Phase 3 Pfizer · Bangor, Maine and 21 other locations · NCT07500506

• Exploring pregnancy and parenting experiences in individuals with Lyme disease

  This study looks at how having Lyme disease affects pregnancy and parenting experiences for those diagnosed with the condition.

  Recruiting Children's National Research Institute · Washington D.C., District of Columbia · NCT06397794

• Assessing immune response in children with Lyme disease

  This study is testing a new blood test to see how children's immune systems respond to Lyme disease to help doctors diagnose it earlier and better.

  Recruiting University Children's Hospital, Zurich · Zurich · NCT06045416

• Assessing neurodevelopmental outcomes in infants exposed to Lyme disease during pregnancy

  This study is trying to see how being exposed to Lyme disease during pregnancy affects the brain development of babies from birth to 18 months.

  Recruiting Children's National Research Institute · Washington D.C., District of Columbia · NCT06026969

• Understanding how human skin reacts to tick bites

  This study is testing how healthy adults' skin reacts to bites from certain ticks to better understand the immune response and help develop ways to resist tick bites.

  Recruiting Phase 1/2 National Institutes of Health Clinical Center (CC) · Bethesda, Maryland · NCT05036707

• Registry and biorepository for rheumatic diseases

  This study is collecting samples and health information from adults with rheumatic diseases at Yale clinics to help researchers learn more about these conditions and improve future treatments.

  Recruiting Yale University · New Haven, Connecticut · NCT04402086

• Monitoring central nervous system infections in Denmark

  This study is looking at how community-acquired central nervous system infections, like meningitis and encephalitis, affect adults in Denmark to better understand their symptoms, treatments, and recovery outcomes.

  Recruiting at 8 sites Aalborg University Hospital · Aalborg and 7 other locations · NCT03418441

• Registry for patients with rare diseases

  This study is creating a central registry for people with rare diseases to help connect them with researchers and improve treatments.

  Recruiting Sanford Health · Sioux Falls, South Dakota · NCT01793168

• Evaluation and treatment of patients with Lyme disease

  This study is trying to understand and treat people with active Lyme disease by looking at their medical history, symptoms, and responses to approved medications.

  Recruiting National Institutes of Health Clinical Center (CC) · Bethesda, Maryland · NCT00028080

• Assessment of patients with suspected post-treatment Lyme disease syndrome

  This study is testing if people who still have symptoms after being treated for Lyme disease might still have the bacteria causing those symptoms, to help understand their ongoing issues better.

  Recruiting National Institutes of Health Clinical Center (CC) · Bethesda, Maryland · NCT00001539

NIH-funded research (newest 40 of 65)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Understanding why some people have ongoing symptoms after Lyme disease

  A long-term study follows people diagnosed with acute Lyme disease to see who develops persistent symptoms and why, with care from a team of Lyme experts.

  NIH research Tufts University Boston · Boston, United States · NIH-11603182

• CSF Protein Map in Post-Treatment Lyme Disease

  A short study to map proteins in spinal fluid of people who had Lyme disease and still feel sick after standard treatment, to understand what’s going on.

  NIH research Bioscience Development, INC. · New York, United States · NIH-11454577

• Lyme disease vaccine research aimed at preventing infection

  Researchers are developing a Lyme disease vaccine by studying how the immune system responds to Borrelia burgdorferi and testing vaccine approaches to prevent illness.

  NIH research University of Toledo Health Sci Campus · Toledo, United States · NIH-11443717

• Lyme disease brain health: tracking brain signals and blood clues after treatment

  This study follows people with early Lyme disease and compares them to healthy volunteers to see how the brain and blood markers change over a year after starting antibiotics.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11399938

• Lyme disease symptoms lingering after treatment may be driven by special bacterial fragments

  A human-friendly look at a study exploring why some Lyme patients keep symptoms after antibiotics and whether tiny fragments from the bacteria are to blame.

  NIH research Northwestern University · Chicago, United States · NIH-11386353

• Understanding Lyme disease immune signals to predict recovery after antibiotics

  A research project at MIT aims to find immune biomarkers that tell which Lyme patients will recover after standard antibiotics and who might have lasting symptoms.

  NIH research Massachusetts Institute of Technology · Cambridge, United States · NIH-11374438

• Imaging Lyme disease with special PET tracers

  A new imaging tool using PET probes is being developed to visualize Lyme disease in people affected by Borrelia burgdorferi sensu lato.

  NIH research Hunter College · New York, United States · NIH-11372972

• Understanding how Lyme disease bacteria adapt to hosts at the genetic level

  Scientists are studying how the Lyme disease bacterium changes its genes to thrive in ticks and mammals, to uncover how it causes infection.

  NIH research Washington State University · Pullman, United States · NIH-11370011

• Microbiology of Post-Treatment Lyme Disease Syndrome in Lyme Arthritis

  This project looks at how different strains of the bacteria that cause Lyme disease might influence lingering symptoms after treatment in people with Lyme arthritis.

  NIH research Tufts University Boston · Boston, United States · NIH-11365930

• Immunology of lingering Lyme symptoms after treatment

  This grant explores why some people continue to feel pain and fatigue after Lyme disease and how their immune systems might drive these lingering symptoms.

  NIH research Tufts University Boston · Boston, United States · NIH-11365928

• PTLDS: Understanding why some Lyme patients stay sick after treatment

  A large study following people with early Lyme disease to learn why some continue to have symptoms after standard antibiotics.

  NIH research Tufts University Boston · Boston, United States · NIH-11365925

• Persistent symptoms after Lyme disease: following patients from diagnosis to recovery

  A nationwide team will follow people diagnosed with acute Lyme disease over time to understand who develops lingering symptoms and why, with the goal of better tests and treatments.

  NIH research Tufts University Boston · Boston, United States · NIH-11365919

• Antibody markers that may predict lingering Lyme symptoms after treatment

  This project looks at specific autoantibodies tied to host lipids to see if they can indicate who might developPost-Treatment Lyme Disease Syndrome (PTLDS) after antibiotics.

  NIH research Tufts University Boston · Boston, United States · NIH-11362336

• Defining how a Bb protein helps Lyme disease bacteria evade the immune system

  Researchers are studying how a protein from the Lyme disease bacteria helps it hide from the immune system, with the goal of preventing infection.

  NIH research Tufts University Boston · Boston, United States · NIH-11362086

• Understanding Post-Treatment Lyme Disease: What Predicts PTLD and How to Identify At-Risk Patients

  This NIH grant looks at why some people recover after Lyme treatment while others develop lingering symptoms, and aims to create a clinical score to identify those at higher risk.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11360571

• Regulatory network of Lyme disease bacteria

  A study to understand how the Lyme disease bacteria controls its genes as it moves between ticks and mammals, which could lead to better prevention and treatment.

  NIH research Indiana University Indianapolis · Indianapolis, United States · NIH-11345865

• How the Lyme bacteria get into the brain and spinal cord

  Researchers will learn how the Lyme disease bacterium Borrelia burgdorferi enters the brain and spinal fluid using mouse models to help people with neurologic Lyme disease.

  NIH research University of South Alabama · Mobile, United States · NIH-11316982

• Multivalent saRNA Lyme Vaccine for Broad Protection

  A new RNA-based vaccine aims to protect people against multiple Lyme disease bacteria using a single low-dose shot.

  NIH research Keylicon Biosciences INC · Brookline, United States · NIH-11311427

• How wild birds help Lyme bacteria survive

  This project learns how wild birds' immune systems allow Lyme disease bacteria to persist and spread, which could help people at risk from tick bites.

  NIH research Tufts University Boston · Boston, United States · NIH-11311270

• How the Lyme disease bacterium controls its harmful genes

  Researchers are mapping how the Lyme bacterium turns on and off the genes that help it survive in ticks and cause infection in people.

  NIH research University of South Florida · Tampa, United States · NIH-11252890

• How the Lyme bacteria change a surface protein to hide from the immune system

  This project looks at how the Lyme disease bacteria swap parts of a surface protein to avoid immune attack, with the goal of helping people affected by Lyme disease.

  NIH research Washington State University · Pullman, United States · NIH-11252546

• PlzA protein and how Lyme bacteria survive in ticks and mammals

  Researchers will look at how a bacterial protein called PlzA helps Lyme bacteria live in ticks and mammals to better protect people at risk of Lyme disease.

  NIH research Virginia Commonwealth University · Richmond, United States · NIH-11231225

• Mapping immune responses to Lyme disease bacteria

  This study is looking at how certain parts of the Lyme disease bacteria can help our immune system recognize and fight it better, which could lead to better vaccines and treatments for people with Lyme disease.

  NIH research Nysdoh/health Research, INC. · Menands, United States · NIH-11215874

• Creating a new vaccine adjuvant to improve Lyme disease vaccines

  This study is testing a new way to make Lyme disease vaccines work better by using a special ingredient that helps boost the immune response, so people can have stronger protection against Lyme disease.

  NIH research Design-Zyme, LLC · Lawrence, United States · NIH-11203936

• Understanding the Immune System in Post-Treatment Lyme Disease Syndrome

  This project aims to understand how the immune system behaves differently in people who continue to have symptoms after Lyme disease treatment compared to those who fully recover.

  NIH research Tufts University Boston · Boston, United States · NIH-11184322

• Understanding Lingering Symptoms After Lyme Disease Treatment

  This project aims to understand why some people continue to feel unwell after being treated for early Lyme disease.

  NIH research Tufts University Boston · Boston, United States · NIH-11184314

• Understanding Persistent Symptoms After Lyme Disease

  This project aims to understand why some people continue to feel sick after being treated for Lyme disease by following them closely from the time they are first diagnosed.

  NIH research Tufts University Boston · Boston, United States · NIH-11184277

• Giving long-lasting Lyme protection to wild white-footed mice

  Researchers aim to create a one-time genetic immunization for white-footed mice to cut the number of infected ticks and lower Lyme disease risk for people.

  NIH research Massachusetts Institute of Technology · Cambridge, United States · NIH-11172237

• Bacterial cell-wall pieces and lingering Lyme symptoms

  This project tests whether unique fragments of the Lyme bacterium's cell wall cause ongoing joint and nerve symptoms in people who had Lyme disease.

  NIH research Northwestern University · Chicago, United States · NIH-11169005

• Unusual bacterial fragments that may cause long-lasting Lyme symptoms

  This work looks at whether pieces of the Lyme bacterium left behind after antibiotics cause ongoing joint pain in people who had Lyme disease.

  NIH research Northwestern University · Chicago, United States · NIH-11168835

• Brain scans and blood tests for lingering neurologic symptoms after Lyme disease

  This project uses brain imaging and blood tests to follow people treated for early Lyme disease who still have ongoing neurologic or cognitive symptoms over one year.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11159491

• Single-step, more accurate blood test for Lyme disease

  This project is creating a single-step blood test that is easier to use and less likely to give false positives so people get faster, clearer Lyme diagnoses.

  NIH research Kephera Diagnostics, LLC · Framingham, UNITED STATES · NIH-11158727

• New Imaging Tools for Lyme Disease

  This project aims to create special imaging agents that can help doctors better find and understand Lyme disease in people.

  NIH research Hunter College · New York, United States · NIH-11142620

• Understanding how a component of Lyme disease bacteria affects symptoms

  This study is looking at how a part of the Lyme disease bacteria might cause ongoing symptoms, like arthritis, in people even after they've been treated with antibiotics, and it aims to help us understand why some patients still feel unwell.

  NIH research Northwestern University at Chicago · Chicago, United States · NIH-11139176

• Understanding how Lyme Disease Bacteria Adapt to Survive

  This project explores how the bacteria that cause Lyme disease change and adapt to successfully live inside both ticks and people.

  NIH research Washington State University · Pullman, United States · NIH-11137610

• Understanding Auto-antibodies in Post-Treatment Lyme Disease Syndrome

  This research looks at specific antibodies in people with Lyme disease to understand why some develop long-lasting symptoms after treatment.

  NIH research Tufts University Boston · Boston, United States · NIH-11136933

• A quick test for Babesia and Lyme disease

  This project is creating a fast, easy-to-use test to find Babesia parasites and Lyme disease antibodies directly from a patient's sample.

  NIH research Biopeptides, INC. · Ridgefield, UNITED STATES · NIH-11127611

• Understanding how genetic factors affect the immune response in Lyme disease.

  This study is looking at how the bacteria that causes Lyme disease can change its surface to hide from our immune system, focusing on a specific protein called VlsE, which could help us find new ways to treat Lyme disease.

  NIH research Washington State University · Pullman, United States · NIH-11127102

• Understanding Why Some People Get Long-Term Symptoms After Lyme Disease Treatment

  This research aims to discover why some individuals continue to experience symptoms after being treated for Lyme disease, while others fully recover.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11123273

• Understanding how Lyme disease bacteria invade the nervous system

  This study is looking at how the bacteria that cause Lyme disease can enter the brain and spinal fluid, and how different types of mice respond to this infection, to help find better treatments for people with serious neurological issues related to Lyme disease.

  NIH research University of South Alabama · Mobile, United States · NIH-11114182

Related topics

Quick answers

How many Lyme Disease clinical trials are recruiting right now?

10, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 4 countries. The most sites are in United States (8 trials), Switzerland (1 trial), Canada (1 trial), Denmark (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 1/2: 1, Phase 3: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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