Understanding how genetic factors affect the immune response in Lyme disease.
Mechanistic Studies of the Role of Genetic Factors in VlsE Antigenic Variation by the Lyme Disease Spirochete
This study is looking at how the bacteria that causes Lyme disease can change its surface to hide from our immune system, focusing on a specific protein called VlsE, which could help us find new ways to treat Lyme disease.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington State University NIH-funded |
| Lab location | 1 site (Pullman, United States) |
| Project ID | NIH-11127102 on NIH RePORTER |
What this research studies
This research investigates how the Lyme disease-causing bacteria, Borrelia burgdorferi, changes its surface proteins to evade the immune system. By studying a specific protein called VlsE, the researchers aim to uncover the genetic mechanisms that allow these changes to occur. They will use advanced genetic techniques to introduce mutations and analyze how these affect the bacteria's ability to survive and cause persistent infections. This work could lead to better understanding and potential new treatments for Lyme disease.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Lyme disease, particularly those experiencing persistent symptoms.
Not a fit: Patients who do not have Lyme disease or those who have already resolved their infection may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for treating or preventing Lyme disease by targeting the mechanisms of immune evasion.
How similar studies have performed: Previous research has shown promise in understanding antigenic variation in other pathogens, suggesting that this approach may yield valuable insights.
Where this research is happening
Pullman, United States
- Washington State University — Pullman, United States (Active)
Researchers
- Principal investigator: Bankhead, Troy Michael — Washington State University
- Study coordinator: Bankhead, Troy Michael
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.