Understanding Why Some People Get Long-Term Symptoms After Lyme Disease Treatment
Determinants of Post-Treatment Phenotypes in Lyme Disease
['FUNDING_R01'] · JOHNS HOPKINS UNIVERSITY · NIH-11123273
This research aims to discover why some individuals continue to experience symptoms after being treated for Lyme disease, while others fully recover.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | JOHNS HOPKINS UNIVERSITY (nih funded) |
| Locations | 1 site (BALTIMORE, UNITED STATES) |
| Trial ID | NIH-11123273 on ClinicalTrials.gov |
What this research studies
We want to understand why some people feel better after Lyme disease treatment and others develop long-lasting symptoms, known as Post-Treatment Lyme Disease (PTLD). We will look at information from patients who have PTLD, healthy individuals, and those with early Lyme disease who are followed over time. By combining advanced statistical and lab methods, we hope to find specific factors that predict who might develop PTLD. Our goal is to create a tool that can help identify patients at higher risk for PTLD in the future.
Who could benefit from this research
Good fit: Ideal candidates for this type of research would include individuals with well-defined Post-Treatment Lyme Disease, healthy controls, and patients recently diagnosed with early Lyme disease.
Not a fit: Patients who have not had Lyme disease or who have fully recovered from it may not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to better ways to identify patients at risk for PTLD and potentially develop new strategies to prevent or treat these long-term symptoms.
How similar studies have performed: While previous data suggest various factors contribute to post-treatment outcomes, a comprehensive longitudinal analysis with direct translation to clinical practice like this has not been performed before.
Where this research is happening
BALTIMORE, UNITED STATES
- JOHNS HOPKINS UNIVERSITY — BALTIMORE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: AUCOTT, JOHN — JOHNS HOPKINS UNIVERSITY
- Study coordinator: AUCOTT, JOHN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.