CSF Protein Map in Post-Treatment Lyme Disease
Official title: CSF Proteome of Post Treatment Lyme Disease
Funded at Bioscience Development, INC. · NIH-11454577 · Data updated 2026-11-12
A short study to map proteins in spinal fluid of people who had Lyme disease and still feel sick after standard treatment, to understand what’s going on.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Bioscience Development, INC. NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | September 1, 2026 |
| Project end | August 31, 2028 |
| Funding year | 2026 |
| Award (this year) | $210,000 |
| NIH project number | 1R21AI196340-01A1 |
| Project ID | NIH-11454577 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults with a history of Lyme disease who continue to experience symptoms after standard antibiotic treatment.
✕Less likely to help
People without PTLDS or those who recovered fully after treatment may not directly benefit.
What this research studies
This project will use advanced mass spectrometry to measure proteins in the cerebrospinal fluid of people with PTLDS. Researchers will compare these proteins to those in people without PTLDS to identify differences that may explain persistent symptoms like fatigue, cognitive issues, and pain. The findings could guide future tests and treatments and help doctors tailor care for PTLDS patients. The work builds on prior MS studies and aims to improve the accuracy and depth of the CSF protein profile by about 50%.
Why it matters
Potential benefit: If successful, the study could lead to better understanding of PTLDS and pave the way for targeted diagnostics and therapies.
How similar studies have gone: Previous work established that PTLDS is a real condition and that CSF analysis can reveal disease-specific signals; this study advances the protein inventory.
Where this research is happening
-
Bioscience Development, INC.
New York, United States Active
Researchers
- Principal investigator: Body, Barbara a. — Bioscience Development, INC.
- Study coordinator: Body, Barbara a.
Related research
Other NIH-funded projects on the same topics.
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Understanding why some people have ongoing symptoms after Lyme disease
A long-term study follows people diagnosed with acute Lyme disease to see who develops persistent symptoms and why, with care from a team of Lyme experts.
-
Lyme disease vaccine research aimed at preventing infection
Researchers are developing a Lyme disease vaccine by studying how the immune system responds to Borrelia burgdorferi and testing vaccine approaches to prevent illness.
-
Lyme disease brain health: tracking brain signals and blood clues after treatment
This study follows people with early Lyme disease and compares them to healthy volunteers to see how the brain and blood markers change over a year after starting antibiotics.
-
Lyme disease symptoms lingering after treatment may be driven by special bacterial fragments
A human-friendly look at a study exploring why some Lyme patients keep symptoms after antibiotics and whether tiny fragments from the bacteria are to blame.
-
Understanding Lyme disease immune signals to predict recovery after antibiotics
A research project at MIT aims to find immune biomarkers that tell which Lyme patients will recover after standard antibiotics and who might have lasting symptoms.
-
Imaging Lyme disease with special PET tracers
A new imaging tool using PET probes is being developed to visualize Lyme disease in people affected by Borrelia burgdorferi sensu lato.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.