Mapping immune responses to Lyme disease bacteria
Innovations in Functional B Cell Epitope Discovery for Lyme Disease
['FUNDING_OTHER'] · NYSDOH/HEALTH RESEARCH, INC. · NIH-11215874
This study is looking at how certain parts of the Lyme disease bacteria can help our immune system recognize and fight it better, which could lead to better vaccines and treatments for people with Lyme disease.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | NYSDOH/HEALTH RESEARCH, INC. (nih funded) |
| Locations | 1 site (MENANDS, UNITED STATES) |
| Trial ID | NIH-11215874 on ClinicalTrials.gov |
What this research studies
This research focuses on identifying specific parts of the Borrelia burgdorferi bacteria that trigger immune responses in humans. By creating detailed maps of B cell epitopes, which are the parts of the bacteria recognized by the immune system, the research aims to improve the development of vaccines, treatments, and diagnostic tests for Lyme disease. This work is particularly important given the high incidence of Lyme disease in the United States, with hundreds of thousands of new cases each year. The approach involves advanced techniques to analyze the surface proteins of the bacteria and their interactions with human immune cells.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals who have been diagnosed with Lyme disease or are at high risk of exposure to Lyme disease.
Not a fit: Patients who do not have Lyme disease or are not at risk of exposure may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective vaccines and treatments for Lyme disease, ultimately reducing the incidence and severity of the infection.
How similar studies have performed: Previous research has shown promise in mapping immune responses to other infectious diseases, suggesting that this approach could be effective for Lyme disease as well.
Where this research is happening
MENANDS, UNITED STATES
- NYSDOH/HEALTH RESEARCH, INC. — MENANDS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MANTIS, NICHOLAS — NYSDOH/HEALTH RESEARCH, INC.
- Study coordinator: MANTIS, NICHOLAS
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.