Target axillary dissection after chemotherapy for locally advanced breast cancer

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to validate the effectiveness of target axillary dissection (TAD) in patients with locally advanced breast cancer who have undergone neoadjuvant chemotherapy. The procedure involves marking a pathological lymph node with a clip before chemotherapy and performing surgery afterward to excise the marked node and sentinel nodes. The study will analyze the false negative rate of the procedure by initially evaluating 30 cases and continuing until 81 cases are collected if necessary. This approach seeks to improve surgical outcomes and lymph node assessment in breast cancer treatment.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Axillary lymph node metastasis proven by cytology
* Clinical or radiological N2a (at least 4 suspicious lymph nodes on axillary ultrasound at diagnosis)
* Extensive T4 subsidiary to axillary lymphadenectomy according to current clinical criteria
* Neoadjuvant chemotherapy

Exclusion Criteria:

* cN3 verified by imaging tests
* N2 due to internal mammary involvement (N2b).
* Tumors whose surrogate molecular subtype is luminal A.
* Patients undergoing neoadjuvant endocrine therapy
* Patients with local recurrences and metastatic tumors.

Where it's running

• Hospital de Bellvitge
  L'Hospitalet de Llobregat, Barcelona, Spain Recruiting
• Hospital Clínico y Provincial de Barcelona
  Barcelona, Spain Recruiting

Study contacts

• Principal investigator: amparo Garcia-Tejedor, MDPhD — Instituto de Investigación Biomédica de Bellvitge (IDIBELL)
• Study coordinator: Amparo García-Tejedor, MDPhD
• Email: agarciat@bellvitgehospital.cat
• Phone: 0034-932607702

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.