Globally useful predictor for cervical cancer treatment response
Official title: Defining a globally accessible and pragmatic predictive signature (GAPPS) for locally advanced cervical cancer
Funded at University of Wisconsin-Madison · NIH-11622628 · Data updated 2026-11-12
This project aims to develop a simple predictive signature to personalize treatment for locally advanced cervical cancer using easy tests and imaging.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Wisconsin-Madison NIH-funded |
| Lab location | 1 site (Madison, United States) |
| Project start | September 8, 2025 |
| Project end | August 31, 2029 |
| Funding year | 2026 |
| Award (this year) | $486,822 |
| NIH project number | 7R01CA301124-02 |
| Project ID | NIH-11622628 on NIH RePORTER |
Who could benefit from this research
✓Could help
Women with locally advanced cervical cancer who are candidates for chemoradiation and may benefit from personalized treatment strategies.
✕Less likely to help
Patients who have early-stage disease or whose cancer biology does not align with the predictive signatures may not benefit.
What this research studies
If funded, researchers will combine imaging data and blood biomarkers to create a practical tool that helps doctors tailor therapies for cervical cancer patients. The work focuses on making risk stratification feasible in settings with limited resources, so treatment can be more targeted and less toxic. The team plans to validate biomarkers that could guide decisions about chemotherapy, radiation, and new therapies in real-world clinical settings.
Why it matters
Potential benefit: Could help doctors personalize treatment to reduce toxicity and improve outcomes for women with locally advanced cervical cancer.
How similar studies have gone: Prior studies suggest that biomarkers and imaging can contribute to risk stratification, but widespread, practical tools are still needed.
Where this research is happening
-
University of Wisconsin-Madison
Madison, United States Active
Researchers
- Principal investigator: Klopp, Ann — University of Wisconsin-Madison
- Study coordinator: Klopp, Ann
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.