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Biliary Tract Cancer (BTC) clinical trials and research

• 19Clinical trials
• 2New in 30 days
• 5Countries

Newest Biliary Tract Cancer (BTC) clinical trials

All recruiting trials (19)

• CR-002 study in adults with advanced solid tumors

  This trial tests CR-002 as a single therapy to see if it is safe and tolerable in adults with locally advanced or metastatic solid tumors

  Recruiting at 3 sites Phase 1/2 Crescent Biopharma, Inc. · Austin, Texas and 2 other locations · NCT07909031

• Primary tumor removal with targeted lymph node removal plus radiation for biliary tract cancer with lymph node spread

  This phase II study tests whether removing the main tumor and select nearby lymph nodes, followed by postoperative radiation, helps patients with biliary tract cancer and lymph node metastases.

  Recruiting Phase 2 Cancer Institute and Hospital, Chinese Academy of Medical Sciences · Beijing, Beijing Municipality · NCT07893392

• Ivonescimab with GEMOX as neoadjuvant and conversion therapy for biliary tract cancer

  This study tests whether adding Ivonescimab to GEMOX can help patients with biliary tract cancer shrink tumors before surgery or enable conversion to operable disease.

  Recruiting Phase 2 Peking Union Medical College Hospital · Beijing, Beijing Municipality · NCT07854600

• Sacituzumab Tirumotecan plus Pembrolizumab in advanced biliary tract cancer

  This study tests whether the combination of Sacituzumab Tirumotecan and Pembrolizumab can help people with advanced biliary tract cancer who have already had at least one approved therapy fail.

  Recruiting Phase 2 Peking Union Medical College Hospital · Beijing, Beijing Municipality · NCT07850791

• Targeted alpha-radiation therapy for NTSR1-positive tumors using SKL35501/SKL35502

  This early-phase trial tests whether a two-part approach—an imaging agent to find NTSR1-expressing tumors and a targeted alpha-ray therapy—can be safely used in adults with certain advanced solid tumors.

  Recruiting Phase 1 SK Life Science, Inc. · Glen Burnie, Maryland and 4 other locations · NCT07812805

• Pemigatinib plus PD-1 inhibitor with or without chemotherapy in FGFR2 fusion/rearrangement-positive cholangiocarcinoma

  This study tests whether combining pemigatinib with a PD-1 inhibitor, with or without chemotherapy, helps people with advanced biliary tract cancer that has FGFR2 fusions.

  Recruiting Phase 2 Peking Union Medical College Hospital · Beijing · NCT07786766

• YMN-136 vaccine for advanced liver, biliary tract, and pancreatic cancers

  A first-in-human dose-escalation study tests whether the YMN-136 vaccine is safe and tolerable for adults with unresectable advanced liver, biliary tract, or pancreatic cancers who have progressed on standard therapies or cannot receive them.

  Recruiting Phase 1 West China Hospital · Chengdu, Sichuan · NCT07763301

• First-line QL1706 plus Gemcitabine and Cisplatin for PD-L1–positive biliary tract cancer

  This study tests whether adding QL1706 to standard gemcitabine and cisplatin can help shrink tumors in adults with PD-L1–positive biliary tract cancer as a first treatment.

  Recruiting Phase 2 Shanghai Zhongshan Hospital · Shanghai · NCT07733115

• Sequential Cryoablation, Relatlimab alfa, and Chemotherapy for Bile Duct Tumors

  This trial tests whether adding cryoablation before immunotherapy with Relatlimab alfa and chemotherapy can help people with unresectable bile duct cancers.

  Recruiting Phase 2 Tianjin Medical University Cancer Institute and Hospital · Tianjin, Tianjin Municipality · NCT07726446

• First-line treatment for biliary tract cancer with iparomlimab, toripalimab, bevacizumab and chemotherapy

  This study tests a combination of iparomlimab and toripalimab with bevacizumab and chemotherapy as the first treatment approach for advanced biliary tract cancer.

  Recruiting Phase 4 Huazhong University of Science and Technology · Wuhan, Hubei · NCT07619235

• Liver-directed chemotherapy plus systemic drugs to downstage biliary tract cancer

  This trial will test whether adding liver-directed arterial chemotherapy to standard systemic treatment can shrink tumors and allow less extensive surgery for adults with untreated biliary tract cancer.

  Recruiting Peking University · Beijing and 1 other locations · NCT07466238

• Select a dose and test nanvuranlat versus physician's best choice for adults with biliary tract cancer

  This trial will test whether nanvuranlat helps adults with advanced biliary tract cancer live longer or control their disease better than a doctor's chosen chemotherapy (FOLFOX or FOLFIRI) or best supportive care after one prior standard therapy.

  Recruiting at 17 sites Phase 3 J-Pharma Co., Ltd. · Duarte, California and 17 other locations · NCT07265674

• In-depth characterisation of biliary strictures and hepato‑pancreato‑biliary focal lesions to support new diagnostic technologies

  This project will collect detailed imaging and tissue data from adults with suspected bile duct, liver, pancreatic, or gallbladder lesions to help develop and test better diagnostic tools.

  Recruiting University of Nottingham · Nottingham · NCT07206355

• ST-01156, a drug that degrades RBM39, for advanced solid cancers

  This trial will test whether ST-01156 is safe and shows early anti-cancer activity in adults (and some teens with Ewing sarcoma) who have advanced or metastatic solid tumors like liver, biliary tract, or Ewing sarcoma.

  Recruiting at 6 sites Phase 1 SEED Therapeutics, Inc. · Duarte, California and 5 other locations · NCT07197554

• Later-line paclitaxel polymer micelle plus immunotherapy for biliary tract cancer

  This trial tests whether giving a paclitaxel polymer micelle combined with immunotherapy helps people with advanced biliary tract cancer who have finished first-line treatment.

  Recruiting Phase 2 Peking Union Medical College Hospital · Beijing, Beijing Municipality · NCT07159204

• AVZO-1418 alone and with other treatments for advanced epithelial solid tumors

  This trial will test whether intravenous AVZO-1418, alone or with other cancer drugs, is safe and helps adults with locally advanced or metastatic epithelial solid tumors, including some lung cancers.

  Recruiting at 27 sites Phase 1/2 Avenzo Therapeutics, Inc. · Gilbert, Arizona and 26 other locations · NCT07038343

• D07001 softgel capsules plus capecitabine vs placebo with capecitabine in advanced biliary tract cancer

  This trial tests whether D07001 softgel capsules added to capecitabine can help people with advanced biliary tract cancer live longer than capecitabine alone.

  Recruiting at 3 sites Phase 3 InnoPharmax Inc. · Tucson, Arizona and 4 other locations · NCT06622057

• Treatment of advanced gastric, pancreatic, and biliary tract cancers with Spevatamig

  This study is testing a new treatment called Spevatamig for people with advanced stomach, pancreatic, or bile duct cancers to see if it works better alone or with other cancer therapies.

  Recruiting at 10 sites Phase 1/2 Phanes Therapeutics · Duarte, California and 10 other locations · NCT05482893

• Evaluating TJ033721 for advanced or metastatic solid tumors

  This study is testing a new drug called TJ033721 to see if it can help people with advanced or metastatic solid tumors, both on its own and in combination with other treatments.

  Recruiting at 7 sites Phase 1 I-Mab Biopharma US Limited · Orange, California and 20 other locations · NCT04900818

Related topics

Quick answers

How many Biliary Tract Cancer (BTC) clinical trials are recruiting right now?

19, as of November 12, 2026. 2 of them were first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 5 countries. The most sites are in China (12 trials), United States (8 trials), South Korea (1 trial), Taiwan (1 trial), United Kingdom (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 7, Phase 1: 4, Phase 1/2: 3, Phase 3: 2. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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