Understanding how immunotherapy and radiation work together for cervical cancer
Official title: Immunogenomic predictors of outcomes in patients with locally advanced cervical cancer treated with immunotherapy and chemoradiation
Funded at Icahn School of Medicine at Mount Sinai · NIH-11133049 · Data updated 2026-11-12
This project aims to find better ways to predict which patients with advanced cervical cancer will respond best to a combination of immunotherapy and chemotherapy with radiation.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | July 1, 2023 |
| Project end | June 30, 2026 |
| Funding year | 2025 |
| Award (this year) | $529,039 |
| NIH project number | 5R01CA276087-04 |
| Project ID | NIH-11133049 on NIH RePORTER |
Who could benefit from this research
✓Could help
Patients with locally advanced cervical cancer who are receiving or have received immunotherapy combined with chemotherapy and radiation would be ideal candidates.
✕Less likely to help
Patients with early-stage cervical cancer or those not undergoing immunotherapy and chemoradiation may not directly benefit from this specific research.
What this research studies
For patients with locally advanced cervical cancer, current treatments often aren't enough, especially when cancer has spread to lymph nodes. This project looks at how the body's immune system and tumor cells change when patients receive immunotherapy alongside chemotherapy and radiation. Researchers are examining blood and tumor samples to understand why some patients respond well and others don't. The goal is to discover new ways to combine these treatments more effectively and identify markers that predict better outcomes, ultimately improving patient care.
Why it matters
Potential benefit: If successful, this work could lead to more personalized and effective treatment plans for patients with advanced cervical cancer, improving their chances of long-term survival.
How similar studies have gone: While previous trials combining these treatments have shown mixed results, this project seeks to address critical knowledge gaps by examining immune responses and optimal treatment sequencing.
Where this research is happening
-
Icahn School of Medicine at Mount Sinai
New York, United States Active
Researchers
- Principal investigator: Zamarin, Dmitriy — Icahn School of Medicine at Mount Sinai
- Study coordinator: Zamarin, Dmitriy
Related research
Other NIH-funded projects on the same topics.
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Globally useful predictor for cervical cancer treatment response
This project aims to develop a simple predictive signature to personalize treatment for locally advanced cervical cancer using easy tests and imaging.
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Community and digital tools to reduce HPV and cervical cancer burden
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Community and digital tools to reduce HPV and cervical cancer in women with HIV
A community- and digital-technology program aims to help girls and young women, including those with HIV, get more HPV vaccination and cervical cancer prevention services.
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mSaada: a mobile tool to boost cervical cancer screening in western Kenya
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.