Examining lymph node biopsy techniques after chemotherapy in advanced breast cancer patients
Sentinel Lymph Node Biopsy after Neoadjuvant Chemotherapy in Patients Presenting with Locally Advanced Breast Cancer: A Prospective Study
This study is looking at whether a less invasive procedure called sentinel lymph node biopsy can help women with locally advanced breast cancer who have received chemotherapy, making it easier to check for cancer spread in the armpit without needing more complicated surgeries.
Quick facts
| Grant type | R03 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Sloan-Kettering Inst Can Research NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10656553 on NIH RePORTER |
What this research studies
This research investigates the effectiveness of sentinel lymph node biopsy (SLNB) in patients with locally advanced breast cancer who have undergone neoadjuvant chemotherapy. The study aims to determine if SLNB can accurately stage the axilla in these patients, potentially reducing the need for more invasive procedures like axillary lymph node dissection. By utilizing advanced mapping techniques and focusing on patients with limited axillary nodal metastases, the research seeks to minimize complications such as lymphedema. Participants will be monitored for accuracy in staging and overall outcomes following their treatment.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with locally advanced breast cancer who are receiving neoadjuvant chemotherapy.
Not a fit: Patients with early-stage breast cancer or those who do not undergo neoadjuvant chemotherapy may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to less invasive surgical options for patients with advanced breast cancer, reducing complications and improving quality of life.
How similar studies have performed: Previous studies have shown promising results with similar approaches in staging breast cancer after chemotherapy, indicating potential for success in this research.
Where this research is happening
New York, United States
- Sloan-Kettering Inst Can Research — New York, United States (Active)
Researchers
- Principal investigator: Barrio, Andrea — Sloan-Kettering Inst Can Research
- Study coordinator: Barrio, Andrea
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.