Using advanced imaging to predict treatment response in rectal cancer
Predicting neoadjuvant treatment response of locally advanced rectal cancer using co-registered endo-rectal photoacoustic and ultrasound imaging
This study is looking to help people with locally advanced rectal cancer by using new imaging methods to better understand how well they respond to treatment before surgery, which could help doctors make smarter choices and possibly spare some patients from unnecessary operations.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project ID | NIH-11088143 on NIH RePORTER |
What this research studies
This research focuses on improving the treatment of locally advanced rectal cancer by utilizing innovative imaging techniques. It aims to enhance the ability to predict how well patients will respond to neoadjuvant treatments, which are given before surgery. By employing co-registered endo-rectal photoacoustic and ultrasound imaging, the study seeks to differentiate between post-treatment scars and residual tumors more accurately. This could lead to better treatment decisions and potentially avoid unnecessary surgeries for patients who achieve complete tumor response.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with locally advanced rectal cancer who are undergoing neoadjuvant treatment.
Not a fit: Patients with early-stage rectal cancer or those who are not receiving neoadjuvant treatment may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could significantly reduce the need for surgery in patients who respond completely to neoadjuvant therapy, thereby minimizing treatment-related complications and improving quality of life.
How similar studies have performed: Previous research has shown promise in using advanced imaging techniques for cancer treatment assessment, indicating that this approach could lead to significant advancements in patient care.
Where this research is happening
Saint Louis, United States
- Washington University — Saint Louis, United States (Active)
Researchers
- Principal investigator: Zhu, Quing — Washington University
- Study coordinator: Zhu, Quing
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.