Improving radiation therapy for advanced cancers using targeted treatments
Molecularly Targeted Radiosensitization of Locally Advanced Cancers
['FUNDING_OTHER'] · UNIVERSITY OF MICHIGAN AT ANN ARBOR · NIH-10917021
This study is looking at ways to make radiation therapy work better for people with hard-to-treat cancers by pairing it with other treatments that target the cancer's specific features, and it aims to find out how to overcome challenges that make radiation less effective.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF MICHIGAN AT ANN ARBOR (nih funded) |
| Locations | 1 site (ANN ARBOR, UNITED STATES) |
| Trial ID | NIH-10917021 on ClinicalTrials.gov |
What this research studies
This research investigates how to enhance the effectiveness of radiation therapy for patients with locally advanced or unresectable cancers by combining it with systemic therapies that target specific molecular drivers of these cancers. The approach involves conducting preclinical studies to understand the mechanisms behind radiation resistance and to identify ways to overcome it. The ultimate goal is to develop pilot clinical trials that will lead to larger phase II trials, assessing the treatment's effectiveness and safety for patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients with locally advanced or unresectable cancers who are not eligible for initial surgery.
Not a fit: Patients with early-stage cancers or those who can undergo surgical intervention may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatment options for patients with advanced cancers, potentially improving survival rates and quality of life.
How similar studies have performed: Previous research has shown promise in combining targeted therapies with radiation, suggesting that this approach could lead to significant advancements in cancer treatment.
Where this research is happening
ANN ARBOR, UNITED STATES
- UNIVERSITY OF MICHIGAN AT ANN ARBOR — ANN ARBOR, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: LAWRENCE, THEODORE S — UNIVERSITY OF MICHIGAN AT ANN ARBOR
- Study coordinator: LAWRENCE, THEODORE S
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Acute Radiation Syndrome