Condition

Knee Arthroplasty, Total clinical trials and research

• 18Clinical trials
• 12Countries

Newest Knee Arthroplasty, Total clinical trials

All recruiting trials (18)

• Adductor canal block versus adductor canal plus IPACK block for pain after total knee replacement

  This study will test whether adding an IPACK block to an adductor canal block reduces pain and the need for pain medicine after total knee replacement.

  Recruiting at 2 sites TC Erciyes University · Kayseri, Talas and 1 other locations · NCT07526831

• 12-month effects of keeping the posterior cruciate ligament during MAKO robotic-assisted total knee replacement

  This trial tests whether keeping the posterior cruciate ligament during MAKO robotic-assisted total knee replacement leads to better function at 12 months for people having a first-time unilateral knee replacement.

  Recruiting at 3 sites Centre Hospitalier Universitaire de Nīmes · Bordeaux and 2 other locations · NCT07489963

• Post-Operative Pain Relief with Zynrelef vs Periarticular Injections in Robot-Assisted Knee Replacement

  This study tests whether the Zynrelef extended-release periarticular injection can reduce pain and opioid use after robot-assisted total knee arthroplasty compared with standard periarticular injections.

  Recruiting Phase 4 Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute) · Cranberry Township, Pennsylvania · NCT07430085

• Cryoneurolysis before total knee replacement surgery

  This trial will test whether freezing the genicular nerves at least 24 hours before total knee replacement reduces long-term pain and improves recovery for adults having primary TKA for osteoarthritis.

  Recruiting Attikon Hospital · Athens · NCT07425457

• Types of persistent pain after hip or knee replacement

  We will re-contact people who still have moderate-to-severe pain after hip or knee replacement to see whether their pain shows signs of nociceptive, neuropathic, or nociplastic mechanisms.

  Recruiting Copenhagen University Hospital, Rigshospitalet · Østerbro, København Ø · NCT07110324

• Low-dose epinephrine with tranexamic acid during knee replacement

  This will test whether giving low-dose epinephrine together with tranexamic acid to people having knee replacement reduces blood loss, clotting complications, and hospital stay.

  Recruiting Phase 4 King Abdullah International Medical Research Center · Riyadh, Riyadh Region · NCT07089251

• Remote follow-up after total knee replacement

  This will test whether replacing routine in-person follow-up visits with remote monitoring and video check-ups works as well and costs less for people aged 50 and older after total knee replacement for osteoarthritis.

  Recruiting Diakonhjemmet Hospital · Oslo, Please Select · NCT07003932

• Is a one-year routine check-up needed after hip or knee replacement?

  This study will see if skipping the routine one-year clinic visit and using check-up on demand is safe and works well for people aged 50 and older after total hip or knee replacement.

  Recruiting at 9 sites JointResearch · Amsterdam and 8 other locations · NCT06971757

• Exploring walking speed after knee replacement surgery

  This study is testing how walking speed changes in people aged 55 and older before and after knee replacement surgery to see if it can help predict their recovery.

  Recruiting Lovisenberg Diakonale Hospital · Oslo · NCT06847113

• Evaluating the AtMoves Knee System for diagnosing knee prosthesis loosening

  This study is testing if the AtMoves Knee System can help doctors better diagnose knee prosthesis loosening in patients who have had knee replacement surgery.

  Recruiting Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) · Nijmegen, Gelderland and 6 other locations · NCT06839807

• Using AI to help patients overcome fear of movement after knee replacement

  This study tests whether using AI to give motivational support can help people who have had knee replacement surgery overcome their fear of moving and improve their recovery.

  Recruiting Kocaeli University · Samsun, Samsun · NCT06758297

• Improving pain control after knee surgery

  This study is testing a new way to manage pain after knee surgery to see if it works better and is safer than the usual method for patients having total knee replacements.

  Recruiting Jessa Hospital · Hasselt, Limburg · NCT06746168

• Comparing computer-assisted and standard techniques in knee replacement surgery

  This study is testing whether using computer-assisted techniques during knee replacement surgery leads to better results and lower costs compared to standard surgery methods for patients needing this procedure.

  Recruiting Istituto Ortopedico Rizzoli · Bologna · NCT06608745

• Comparing robotic-assisted and conventional knee replacement techniques

  This study is testing if robotic-assisted knee replacement surgery helps adults recover better and have fewer problems compared to traditional knee replacement surgery.

  Recruiting at 2 sites Danderyd Hospital · Hässleholm and 1 other locations · NCT06389435

• Using Losartan to Reduce Knee Scarring After Surgery

  This study is testing if the medication Losartan can help people recover better from knee surgery by reducing scarring and improving movement.

  Recruiting Phase 1/2 Steadman Philippon Research Institute · Vail, Colorado · NCT06108063

• Collecting data on the Truliant Knee System after surgery

  This study is collecting information from people who have had or will have the Truliant knee replacement to see how well it works and how safe it is after surgery.

  Recruiting at 5 sites Exactech · Aurora, Colorado and 4 other locations · NCT05653102

• Evaluating different alignment techniques in knee replacement surgery

  This study is testing two different knee replacement surgery techniques to see which one helps patients recover better and feel happier after the operation.

  Recruiting Exactech · Barcelona · NCT05516381

• Comparing walking analysis after knee replacement using different alignment methods

  This study is testing which of two knee replacement methods helps people aged 55 to 80 with severe knee arthritis walk better and feel more satisfied after surgery.

  Recruiting Hospices Civils de Lyon · Lyon · NCT04226339

Related topics

Quick answers

How many Knee Arthroplasty, Total clinical trials are recruiting right now?

18, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 12 countries. The most sites are in United States (3 trials), Netherlands (2 trials), Turkey (Türkiye) (2 trials), Norway (2 trials), France (2 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 4: 2, Phase 1/2: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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