Types of persistent pain after hip or knee replacement
Characteristics of Persistent Pain Composition Following Total Hip or Knee Arthroplasty: a Descriptive Study
We will re-contact people who still have moderate-to-severe pain after hip or knee replacement to see whether their pain shows signs of nociceptive, neuropathic, or nociplastic mechanisms.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 100 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Rigshospitalet, Denmark Academic / other |
| Locations | 1 site (Østerbro, København Ø) |
| Trial ID | NCT07110324 on ClinicalTrials.gov |
What this trial studies
Approximately 100 consenting patients with persistent postoperative pain (NRS >3) identified from a pool of about 7,000 respondents will be re-invited to complete standardized pain questionnaires. Neuropathic pain will be measured with the DN4, nociplastic pain with IASP criteria plus the Fibromyalgia Survey Questionnaire, and nociceptive pain using the KOOS/HOOS pain domains. Primary outcomes are the prevalence of potential nociplastic pain and the proportion of patients experiencing significant pain in two or more mechanistic categories, with secondary analyses comparing baseline versus follow-up DN4, FSQ, and KOOS/HOOS distributions and differences by neuropathic pain status. The results are intended to inform more targeted pre- and postoperative pain management strategies for arthroplasty patients.
Who should consider this trial
Good fit: Ideal candidates are people who had total or unicompartmental hip or knee replacement, continue to have moderate-to-severe pain (NRS >3), consent to be contacted, and have not had re-operation or major postoperative complications.
Not a fit: Patients who have had re-operation or major postoperative complications (infection, thromboembolism, prosthesis fracture or dislocation) or who do not want to be contacted are excluded and unlikely to benefit from this study's findings.
Why it matters
Potential benefit: If successful, the results could help clinicians tailor pain treatments by identifying patients with neuropathic or nociplastic pain who may benefit from different therapies than standard post-arthroplasty care.
How similar studies have performed: Previous research has reported neuropathic and nociplastic features after arthroplasty, but re-characterizing a cohort with this specific combination of DN4, IASP/FSQ, and KOOS/HOOS measures is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * All patients with persistent moderate-severe pain (NRS\>3) after THA, TKA and UKA * Acceptance to be contacted. Exclusion Criteria: * Re-operation * Luxation * Do not want to be contacted * Post-operative complications such as prosthesis infection, thromboembolism or fracture of the prosthesis.
Where this trial is running
Østerbro, København Ø
- Rigshospitalet — Østerbro, København Ø, Denmark (Recruiting)
Study contacts
- Study coordinator: Milan Mohammad, MD
- Email: milanmohammad@hotmail.com
- Phone: +4560162372
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.