Improving pain control after knee surgery

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to compare the effectiveness of an iPACK block combined with a femoral triangle block against traditional surgical local infiltration analgesia (LIA) for patients undergoing unilateral total knee arthroplasty (TKA). The hypothesis is that the iPACK approach is at least as effective as the standard LIA while potentially reducing risks associated with nerve damage and other complications. The study will involve administering locoregional anesthesia using ropivacaine to assess pain management outcomes post-surgery.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* ASA I-III
* BMI 17-35 kg/m2
* Patient is able to give informed consent
* Patient is scheduled for TKA

Exclusion Criteria:

* Refusal of patient
* Inability to communicate due to language or neurologic barriers
* Bilateral TKA or unilateral knee arthroplasty
* Chronic opioid use (including partial opioid agonists) + chronic pain patients:
* Use of atypical analgesics (gabapentin, pregabalin, …)
* History of Sudeck atrophy
* History of \>3 chronic pain consultations
* Contraindications for spinal anesthesia
* Patient refusal
* Local infection
* Aberrant coagulation (according to the latest ESRA guidelines)
* Severe spinal canal stenosis
* Intracranial hypertension
* History of neurological injury in the affected limb
* Contraindications for local anesthetics
* Allergy for local anesthetics
* Absolute contraindications for NSAIDs or paracetamol
* Proven allergy for NSAID's (including ASA syndrome) or paracetamol
* Severe renal function impairment (eGFR \<30 ml/min/1.73 m2)
* Active or recent (\<6 months) history of gastric ulcera/perforations/bleeding
* Crohn disease or colitis ulcerosa
* Liver function impairment or severe renal function impairment (eGFR \<30 ml/min/1.73 m2)
* Pregnancy or breast-feeding

Where it's running

• Jessa Hospital
  Hasselt, Limburg, Belgium Recruiting

Study contacts

• Study coordinator: Bjorn Stessel, MD, PhD
• Email: bjorn.stessel@jessazh.be
• Phone: 003211222107

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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• Low-dose epinephrine with tranexamic acid during knee replacement

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.