Adductor canal block versus adductor canal plus IPACK block for pain after total knee replacement
Official title: Comparison of the Analgesic Efficacy of Adductor Canal Block Versus Adductor Canal Block Combined With Local Anesthetic Infiltration Between the Popliteal Artery and the Capsule of the Knee (IPACK) in Patients Undergoing Knee Surgery
Run by TC Erciyes University · NCT07526831 · Data updated 2026-11-12
This study will test whether adding an IPACK block to an adductor canal block reduces pain and the need for pain medicine after total knee replacement.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 60 (estimated) |
| Sponsor | TC Erciyes University Academic / other |
| Locations | 2 sites (Kayseri, Talas and 1 other locations) |
| Status | Recruiting |
| Started | April 15, 2026 |
| Main results expected | April 15, 2028 |
| Study ends | May 1, 2028 |
| Registry record updated | May 14, 2026 |
| Trial ID | NCT07526831 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults scheduled for total knee arthroplasty with ASA physical status I–III who can receive peripheral nerve blocks and consent to participate.
✕Probably not a fit
Patients with a known allergy to local anesthetics, those who refuse nerve blocks, or people with contraindications to regional anesthesia may not receive benefit.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
In patients undergoing total knee arthroplasty, clinicians will compare postoperative pain and analgesic use between those receiving an ultrasound-guided adductor canal block alone and those receiving an adductor canal block combined with an IPACK block. The observational protocol groups patients into Adductor Canal Block (Group I) and Adductor Canal + IPACK Block (Group II) based on the analgesic technique used. Outcomes include postoperative pain scores and analgesic requirements, with blocks performed under ultrasound guidance. Eligible adults are ASA I–III and exclusions include allergy to the study medication or refusal to participate.
Why it matters
Potential benefit: If successful, adding an IPACK block could improve pain control and reduce opioid use after total knee arthroplasty.
How similar studies have gone: Previous reports and trials have shown that combining an IPACK block with an adductor canal block can provide better posterior knee analgesia and lower opioid consumption in many studies, though results are not uniformly conclusive.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * ASA (American Society of Anesthesiologists) I- ASA II-ASA III Patients Exclusion Criteria: * history of allergy to the study medication * refusal to participate
Where it's running
-
Sibel Pehlivan
Kayseri, Talas, Turkey (Türkiye) Recruiting -
Sibel Seckin Pehlivan
Kayseri, Turkey (Türkiye) Recruiting
Study contacts
- Study coordinator: Sibel Pehlivan, DR
- Email: Sibelpehlivan@erciyes.edu.tr
- Phone: 0905052532919
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.