Improving measures of nutrition, inflammation, kidney function, body composition, and hydration in older adults
Methods for Assessing Nutrition, Inflammation, Kidney Function, Aging, Body Composition, and Hydration Among Older Patients - An Observational Study (MIKADO)
This project will test whether modern blood tests and body-measure techniques give more accurate estimates of nutrition and kidney health for hospitalized people aged 65 and older.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 500 (estimated) |
| Ages | 65 Years and up |
| Sex | All |
| Sponsor | Hvidovre University Hospital Academic / other |
| Locations | 1 site (Copenhagen) |
| Trial ID | NCT07501195 on ClinicalTrials.gov |
What this trial studies
This observational project compares modern biomarkers, body-composition measures, and hydration assessments with current clinical and laboratory gold standards to improve diagnosis of malnutrition and kidney disease in older hospitalized patients. Participants are recruited at Hvidovre Hospital across several groups, including acutely admitted patients, people aged 90+, those with BMI ≥35, long-term high-dose prednisolone users, and non-traumatic lower-limb amputees. The study collects blood-based biomarkers, inflammation markers, body composition and hydration measurements and compares them to established reference methods. It also analyzes how age, inflammation, body composition and hydration affect diagnostic accuracy.
Who should consider this trial
Good fit: Hospitalized adults aged 65 and older who can read and speak Danish and cooperate, including specific subgroups such as acutely admitted patients, people aged 90+, individuals with BMI ≥35, long-term high-dose prednisolone users, and non-traumatic lower-limb amputees.
Not a fit: Patients in isolation, receiving terminal care, actively suicidal, on immune-suppressing treatment, with oedema, currently undergoing cancer treatment, or unable to read/speak Danish or cooperate cognitively are excluded and unlikely to benefit from participation.
Why it matters
Potential benefit: If successful, this work could lead to more accurate and earlier identification of malnutrition and kidney problems, enabling better-targeted care for older patients.
How similar studies have performed: Previous research has shown individual biomarkers and body-composition methods can improve diagnostic accuracy, but applying and comparing multiple modern modalities together in older hospitalized populations is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * 65 years or older (group 1, 4 and 5) * 90 years or older (group 3) * Acute admission (group 1, 2) * Cognitively able to cooperate (group 1) * Able to read and speak Danish (group 1, 2, 3, 4, 5, 6) * BMI ≥ 35 kg/m2 (group 4) * Prednisolon treatment for COPD (≥ 37,5 mg daily) (group 5) * Amputation(s) of crus or femur (non-traumatic) (group 6) Exclusion Criteria: * Isolation (group 1, 2, 3, 4, 5, 6) * Terminal treatment (group 1, 2, 3, 4, 5, 6) * Suicidal (group 1, 2, 3, 4, 5, 6) * Active Immune suppressing treatment (group 2, 3, 4, 5, 6) * Oedemas (group 2, 3, 4, 5, 6) * In active treatment for cancer (group 2, 3, 4, 5, 6)
Where this trial is running
Copenhagen
- Hvidovre Hospital — Copenhagen, Denmark (Recruiting)
Study contacts
- Principal investigator: Ove Andersen, Professor — Department of clinical research, Copenhagen University Hospital
- Study coordinator: Ove OA Andersen, Professor
- Email: ove.andersen@regionh.dk
- Phone: 004538626719
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.