Using remote ischemic preconditioning to protect organs during hip surgery
Effects of Remote Ischaemic Preconditioning in Cemented Total Hip Arthroplasty: Randomized Controlled Trial
This study is testing if a special technique called remote ischemic preconditioning can help protect the hearts, kidneys, and brains of older patients during hip surgery.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 200 (estimated) |
| Ages | 65 Years to 90 Years |
| Sex | All |
| Sponsor | University of Tartu Academic / other |
| Locations | 1 site (Tartu, Tartu) |
| Trial ID | NCT06323018 on ClinicalTrials.gov |
What this trial studies
This study investigates the effects of remote ischemic preconditioning (RIPC) on patients undergoing cemented hip arthroplasty, particularly focusing on its potential to protect multiple organs from complications associated with the procedure. Cemented hip arthroplasty is often performed on elderly patients with osteoarthritis and multiple comorbidities, who are at risk for bone cement implantation syndrome. The study aims to determine if RIPC can mitigate cardiovascular, renal, and neurological complications that may arise during and after surgery. Participants will be randomly assigned to receive either RIPC or a sham treatment to assess the protective effects of the intervention.
Who should consider this trial
Good fit: Ideal candidates are patients over 65 years old who are scheduled for total cemented hip arthroplasty.
Not a fit: Patients with a history of peripheral artery disease or contraindications to RIPC may not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could significantly reduce postoperative complications and improve recovery outcomes for elderly patients undergoing hip surgery.
How similar studies have performed: Previous studies have shown that remote ischemic preconditioning can provide protective effects in non-cardiac surgeries, suggesting potential for success in this context.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * age \>65 years * undergoing total hip cemented hip arthroplasty Exclusion Criteria: * previously diagnosed peripheral artery disease on both upper limb * RIPC is contraindicated
Where this trial is running
Tartu, Tartu
- University of Tartu — Tartu, Tartu, Estonia (Recruiting)
Study contacts
- Study coordinator: Kaspar Tootsi, PhD
- Email: kaspar.tootsi@kliinikum.ee
- Phone: +372 7318282
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.