Investigating chronic kidney disease in agricultural communities
Official title: Chronic Kidney Diseases of Uncertain Etiology (CKDu) in Agricultural Communities (CURE) Research Consortium - SDCC
Funded at Research Triangle Institute · NIH-10890138 · Data updated 2026-11-12
This study is looking into chronic kidney disease that affects farming communities, and it aims to find out what causes it and how it develops, so if you're a patient, your health information and samples could really help us learn more about this condition.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Research Triangle Institute NIH-funded |
| Lab location | 1 site (Research Triangle Park, United States) |
| Project start | August 25, 2021 |
| Project end | June 30, 2026 |
| Funding year | 2024 |
| Award (this year) | $1,143,873 |
| NIH project number | 5U24DK130043-04 |
| Project ID | NIH-10890138 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation include individuals living in agricultural communities who are experiencing symptoms of chronic kidney disease or have a family history of the condition.
✕Less likely to help
Patients with chronic kidney disease attributed to known causes, such as diabetes or hypertension, may not benefit from this research.
What this research studies
This research focuses on understanding chronic kidney disease of uncertain etiology (CKDu), which is increasingly affecting agricultural communities worldwide. The project aims to identify the causes, progression, and biological markers of CKDu through a collaborative effort involving multiple institutions. By developing a standardized study protocol, the research will gather data from various regions to uncover genetic and environmental risk factors associated with CKDu. Patients may be involved in providing samples and health information to help advance knowledge in this area.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and management of chronic kidney disease, potentially resulting in better health outcomes for affected individuals.
How similar studies have gone: Previous research has shown promise in understanding chronic diseases through collaborative and multi-regional studies, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Research Triangle Institute
Research Triangle Park, United States Active
Researchers
- Principal investigator: Lebov, Jill — Research Triangle Institute
- Study coordinator: Lebov, Jill
Related research
Other NIH-funded projects on the same topics.
-
Chronic Kidney Disease of Unknown Cause in Agricultural Communities
A wide study to find what causes a serious kidney disease that affects workers in farming areas, by looking at people in high-risk regions.
-
Ubiquitin D as a potential target to help NASH, kidney disease, and liver cancer
A new approach targets a protein called UBD to help people with fatty liver disease, kidney disease, and liver cancer that can arise from liver disease.
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Understanding Ubiquitin D for Liver and Kidney Diseases
This project looks at a protein called Ubiquitin D to find new ways to help people with liver conditions like NASH and HCC, and also chronic kidney disease.
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Understanding CKDu in agricultural communities
This project brings researchers together to find the causes and clues behind chronic kidney disease of unknown cause in farming communities so people affected can get better prevention and care.
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Improving kidney health in patients with chronic kidney disease through a systems biology approach.
This study is looking at how low oxygen levels affect kidney cells in people with chronic kidney disease, and it aims to create a helpful scoring system to better understand how these changes relate to patient outcomes, which could lead to improved treatments for those living with this condition.
-
Metabolic Boost to Kidney Health in ADPKD
A Johns Hopkins-led study is exploring how fueling kidney cells with fats and FGF21 signals could slow kidney disease in adults with ADPKD.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.