Condition

Carcinoma, Squamous Cell clinical trials and research

• 14Clinical trials
• 29Countries

Newest Carcinoma, Squamous Cell clinical trials

All recruiting trials (14)

• Intratumoral injection of N17350 in advanced solid tumors

  Aims to see if injected N17350 can shrink or control tumors in adults with advanced solid cancers who have few other options.

  Recruiting at 7 sites Phase 1/2 Onchilles Pharma Inc · Los Angeles, California and 8 other locations · NCT07339176

• Zanzalintinib with pembrolizumab and cetuximab for recurrent or metastatic head and neck squamous cell cancer

  This trial tests whether adding the oral drug zanzalintinib to pembrolizumab and cetuximab is safe and finds the best dose for adults with recurrent or metastatic head and neck squamous cell cancer.

  Recruiting Phase 1 University of Chicago · Chicago, Illinois · NCT06912087

• Lenvatinib plus pembrolizumab for anal or rectal cancer that progressed after first treatment

  This trial gives lenvatinib with pembrolizumab to people whose anorectal squamous cell cancer has spread or gotten worse after first-line chemotherapy or chemoradiation to see if the combination controls the cancer and is safe.

  Recruiting Phase 2 University of Chicago · Chicago, Illinois · NCT06669572

• Neoadjuvant targeted therapy for lung cancer patients with specific mutations

  This study is testing if a targeted therapy called osimertinib can safely shrink tumors in lung cancer patients with specific mutations before surgery to help improve their treatment outcomes.

  Recruiting Phase 2 The First Affiliated Hospital of Guangzhou Medical University · Guangzhou, Guangdong · NCT06383728

• Preventing skin cancer in organ transplant recipients using nicotinamide

  This study is testing if taking nicotinamide, a form of Vitamin B3, can help prevent skin cancer in organ transplant recipients who are at high risk.

  Recruiting at 6 sites Phase 3 Women's College Hospital · Calgary, Alberta and 6 other locations · NCT05955924

• Combination of Anlotinib and TQB2450 for Esophageal Cancer Treatment

  This study is testing if combining two medications, Anlotinib and TQB2450, can help people with esophageal cancer stay cancer-free after surgery.

  Recruiting Phase 2 Jiangxi Provincial Cancer Hospital · Nanchang, Jiangxi · NCT05252078

• Treatment for elderly patients with advanced head and neck cancer using a new drug and radiation

  This study is testing a new drug combined with radiation to see if it helps elderly patients with advanced head and neck cancer feel better compared to just radiation or radiation with another drug.

  Recruiting at 134 sites Phase 3 Johnson & Johnson Enterprise Innovation Inc. · Birmingham, Alabama and 195 other locations · NCT04892173

• Observing HPV DNA and genetic markers in oropharyngeal cancer

  This study is testing if checking for certain gene changes and HPV DNA in the blood can help predict if oropharyngeal cancer will come back in newly diagnosed patients.

  Recruiting at 2 sites UNC Lineberger Comprehensive Cancer Center · Rochester, Minnesota and 2 other locations · NCT04564989

• Combining TGF-β and PDL-1 inhibition with chemoradiation for esophageal cancer

  This study is testing if a new treatment combining a drug called bintrafusp alfa with standard chemotherapy and radiation can be safely given to patients with advanced esophageal cancer that can't be surgically removed.

  Recruiting Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) · Amsterdam · NCT04481256

• Investigating BCA101 for advanced solid tumors driven by EGFR

  This study is testing a new treatment called BCA101 to see if it can help people with advanced solid tumors that are driven by EGFR, especially those who haven't responded to other therapies.

  Recruiting at 21 sites Phase 1 Bicara Therapeutics · La Jolla, California and 20 other locations · NCT04429542

• Blood test for cancer DNA in head and neck cancer patients

  This study is testing if a blood test that looks for cancer DNA can help doctors understand how head and neck cancer behaves before and after surgery, and see if it can predict if the cancer will come back.

  Recruiting UNC Lineberger Comprehensive Cancer Center · Chapel Hill, North Carolina · NCT04099290

• Treatment for squamous cell carcinoma using 5-fluorouracil and imiquimod

  This study is testing a new way to treat squamous cell carcinoma on the legs by using a combination of a chemotherapy drug and a topical treatment to see if it helps the tumors shrink without needing surgery.

  Recruiting Phase 1 University of Pittsburgh · Pittsburgh, Pennsylvania · NCT03370406

• Guiding surgery for early-stage oral squamous cell carcinoma using tumor budding.

  This study is testing whether checking for tumor budding can help doctors decide if patients with early-stage oral cancer need to have their lymph nodes removed during surgery.

  Recruiting Sun Yat-sen University · Guangzhou, Guangdong · NCT02743832

• Chemotherapy for advanced oral cancer patients with high cyclin D1 expression

  This study is testing if a specific chemotherapy treatment can help people with advanced oral cancer who have high levels of a protein called cyclin D1 live longer and stay cancer-free after treatment.

  Recruiting Phase 2 Shanghai Jiao Tong University School of Medicine · Shanghai, Shanghai Municipality · NCT02290145

Related topics

Quick answers

How many Carcinoma, Squamous Cell clinical trials are recruiting right now?

14, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 29 countries. The most sites are in United States (8 trials), China (5 trials), Canada (3 trials), Australia (2 trials), Netherlands (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 4, Phase 1: 3, Phase 3: 2, Phase 1/2: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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