Analyzing the genetic profiles of head and neck tumors
Molecular and Genomic Profiling of Head and Neck Tumors to Explore Biomarkers Associated With Prognosis and Response to Therapy
Montefiore Medical Center · NCT00200486
This study is trying to see if looking at the genes in head and neck tumors can help predict how well patients will respond to treatment and their overall outcomes.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 1000 (estimated) |
| Sex | All |
| Sponsor | Montefiore Medical Center (other) |
| Drugs / interventions | immunotherapy |
| Locations | 1 site (The Bronx, New York) |
| Trial ID | NCT00200486 on ClinicalTrials.gov |
What this trial studies
This observational study aims to investigate the genetic profiles of head and neck tumors and their correlation with treatment responses and patient outcomes. Utilizing genetic microarray analysis, the research identifies distinct gene expression patterns that may serve as better predictors of prognosis compared to traditional clinical variables. The study focuses on isolating specific genes that change expression during tumor progression and metastasis, providing insights into the malignant transformation process. By analyzing tumor samples, the study seeks to enhance understanding of how genetic factors influence cancer behavior and treatment efficacy.
Who should consider this trial
Good fit: Ideal candidates include individuals with actual or suspected malignant or non-malignant tumors of the head and neck who are undergoing biopsy or resection.
Not a fit: Patients with insufficient tissue available for both standard diagnostic evaluation and study specimen will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved prognostic tools and personalized treatment strategies for patients with head and neck cancer.
How similar studies have performed: Previous studies using genetic profiling in similar contexts have shown promising results, indicating potential for success in this approach.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * actual or suspected malignant or non-malignant tumors of the head and neck * planned biopsy and/or resection, or availability of paraffin embedded or stored frozen tumor tissue for non-genetic analysis Exclusion Criteria: * insufficient tissue available for both standard diagnostic evaluation and study specimen
Where this trial is running
The Bronx, New York
- Stelby Augustine — The Bronx, New York, United States (RECRUITING)
Study contacts
- Principal investigator: Richard V Smith, MD — Montefiore Medical Center
- Study coordinator: Stelby Augustine, RN
- Email: staugust@montefiore.org
- Phone: 718-920-7054
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Head and Neck Neoplasms, genetic microarray, head and neck cancer