Imaging for personalized treatment of head and neck cancer

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study focuses on improving radiotherapy for head and neck cancers by utilizing advanced imaging techniques, specifically PET and MRI. By capturing images before and during treatment, the study aims to quantify intratumoral characteristics such as oxygenation and metabolism, which can help tailor radiotherapy to individual patient needs. The goal is to establish a clinical workflow that enhances the precision of radiotherapy, potentially leading to better treatment outcomes and fewer side effects for patients. The study will also explore the integration of proton therapy as a future treatment option.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* willing and able to give full written consent according to the protocol approved by the Regional Ethics Committee
* histologically confirmed squamous cell carcinoma in the head neck region (pharynx, larynx, oral cavity or sinonasal area)
* locally advanced disease without sign of dissemination (T3/T4 and/or N1-3, M0) on diagnostic imaging
* scheduled for definitive radiotherapy with curative intent with or without concomitant chemotherapy
* adequate renal function: Creatinine clearance ≥ 60 ml/minute
* lymph node metastasis from cancer of unknown primary of the upper neck (i.e. level II-III) were PET/CT is negative outside the head-neck region can be considered for inclusion at the discretion of the study investigators.

Exclusion Criteria:

* general contraindications for MRI (pacemaker, aneurysm clips, any form of metal in the body, severe claustrophobia)
* serious comorbidity (including previous or othe cancer) that in the opinion of the investigator would compromise the patient's ability to complete the study of interfere with the evaluation of the study objectives (e.g. poorly controlled diabetes mellitus)
* histologically confirmed SCC of same or other origin within the last five years
* patient wants to withdraw for any reason during the study

Where it's running

• St Olavs Hospital, Department of Oncology
  Trondheim, Norway Recruiting
• University Hospital of North Norway
  Tromsø, Norway Not yet recruiting

Study contacts

• Study coordinator: Miriam Alsaker, phd
• Email: mirjam.alsaker@ntnu.no
• Phone: +47 73598709

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.