Testing pacritinib for treating severe chronic graft-versus-host disease after stem cell transplant

-INCLUSION CRITERIA:

1. Moderate or severe cGVHD (after allogeneic hematopoietic stem cell transplantation) diagnosed and staged per NIH criteria
2. cGVHD that did not respond to \>=2 lines of prior systemic therapy.

   Disease that has failed prior systemic therapy will be defined as follows:

   a) For prior corticosteroid-containing regimens, disease that:

   i) recurs after achievement of a CR, or

   ii) progresses after achievement of a PR, or

   iii) progresses after at least 1 week of prednisone equivalent of 1 mg/kg/day, or

   iv) is stable and persistent after at least 4 weeks of a prednisone equivalent of 0.5 mg/kg/day

   OR,

   b) For other systemic therapies, disease that:

   i) recurs after achievement of CR, or

   ii) progresses after achievement of a PR, or

   iii) is stable and persistent despite 4 weeks of therapeutic dosing of systemic therapy
3. Karnofsky performance score \>=60%
4. Age \>=18 years.
5. If participant is taking systemic therapy for cGVHD at the time of enrollment, they must be on a stable or tapering dose in the preceding 4 weeks.
6. Participants must have adequate organ and marrow function as defined below:

   * absolute neutrophil count \>=1,000/mcL
   * platelets \>=50,000/mcL
   * total bilirubin \<=1.5 X institutional upper limit of normal

   OR

   \<=3 X institutional upper limit of normal in participants with Gilbert's syndrome
   * AST(SGOT)/ALT(SGPT) \<=3 X institutional upper limit of normal
   * eGFR \>= 35 mL/min per CKD-EPI 2021
7. Primary malignancy for which the participant received transplant has been in complete clinical remission and stable for 3 months prior to enrollment on study.
8. Individuals of child-bearing potential (IOCBP) and individuals able to father a child with a partner able to become pregnant who are sexually active must agree to use one (1) highly effective (e.g., intrauterine system containing levonorgestrel intrauterine devices, surgical) or two (2) effective forms of contraception (e.g., barrier method) at study entry, for the duration of study treatment, and for at least 30 days after last study drug exposure.
9. Ability of participant to understand and the willingness to sign a written informed consent document.

EXCLUSION CRITERIA:

1. Acute GVHD that is active as defined by exhibiting current signs or symptoms of disease without any chronic GVHD (classic and late-acute GVHD per NIH consensus criteria); participants with a clinical presentation consistent with overlapping acute GVHD with concurrent chronic GVHD will be eligible
2. Treatment with ruxolitinib within 24 hours, or ibrutinib within the \<=14 days prior to treatment initiation.
3. Active HIV-1 (detectable HIV viral load), or Hepatitis B (HBV) and/or Hepatitis C (HCV) infection (positive HBV or HCV viral load in the setting of positive HBV core antibody or surface antibody or HCV antibody).
4. Participants with the following cardiac conditions at screening:

   * symptomatic congestive heart failure
   * unstable angina pectoris
   * uncontrolled cardiac dysrhythmias
   * QTc(F) prolongation \>450 ms or other factors that increase the risk for QT prolongation (i.e., heart failure, or a history of long QT interval syndrome).
5. Left ventricular ejection fraction \<= 50% by transthoracic echocardiogram (TTE) at screening.
6. Participants with poor pulmonary function as defined by a forced expiratory volume in the first second (FEV1) \<= 39% calculated using the USA-ITS-NIH equation.
7. Participants with evidence of ongoing hemorrhage, active signs/symptoms of bleeding, or history of severe bleeding complications in the one year prior to enrollment.
8. Concurrent treatment with any other investigational agents.
9. Concurrent use of strong CYP3A4 inducers or inhibitors, must stop 2 weeks prior study drug initiation.
10. Known hypersensitivity to JAK inhibitors.
11. Participants who are unwilling to accept blood transfusions.
12. Pregnancy or breastfeeding.
13. Participants with any active, uncontrolled viral, bacterial, or fungal infection are excluded.
14. Other malignancy except non-melanoma skin cancer or carcinoma in situ of the cervix or breast which requires active treatment.
15. Uncontrolled intercurrent illness evaluated by history, physical exam and chemistries or situation that would limit compliance with study requirements.