Understanding and treating chronic graft-versus-host disease
Mechanisms and Therapy of Chronic Graft-vs.-Host Disease
This study is looking at how chronic graft-versus-host disease (cGVHD) affects the lungs after a stem cell transplant, and it aims to find new ways to help patients by understanding the immune cells involved in this condition.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Dana-Farber Cancer Inst NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10914131 on NIH RePORTER |
What this research studies
This research focuses on chronic graft-versus-host disease (cGVHD), a serious condition that can occur after a stem cell transplant, affecting various organs, particularly the lungs. The study aims to explore the mechanisms behind cGVHD and its pulmonary manifestation, Bronchiolitis Obliterans Syndrome (BOS), which can lead to severe lung damage and high mortality rates. By investigating the metabolic pathways of immune cells involved in cGVHD, the researchers hope to identify new treatment strategies that could improve patient outcomes. Patients may be monitored for their immune response and metabolic changes to better understand the disease's progression and treatment efficacy.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals who have undergone allogeneic hematopoietic stem cell transplants and are experiencing symptoms of chronic graft-versus-host disease.
Not a fit: Patients who have not undergone stem cell transplants or those without symptoms of chronic graft-versus-host disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to novel therapies that significantly improve the quality of life and survival rates for patients suffering from chronic graft-versus-host disease.
How similar studies have performed: Previous research has shown promise in understanding the mechanisms of graft-versus-host disease, but this specific approach focusing on metabolic pathways is relatively novel.
Where this research is happening
Boston, United States
- Dana-Farber Cancer Inst — Boston, United States (Active)
Researchers
- Principal investigator: Cutler, Corey S — Dana-Farber Cancer Inst
- Study coordinator: Cutler, Corey S
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.