Understanding and treating chronic graft-versus-host disease

Who could benefit from this research

What this research studies

This research focuses on chronic graft-versus-host disease (cGVHD), a serious condition that can occur after a stem cell transplant, affecting various organs, particularly the lungs. The study aims to explore the mechanisms behind cGVHD and its pulmonary manifestation, Bronchiolitis Obliterans Syndrome (BOS), which can lead to severe lung damage and high mortality rates. By investigating the metabolic pathways of immune cells involved in cGVHD, the researchers hope to identify new treatment strategies that could improve patient outcomes. Patients may be monitored for their immune response and metabolic changes to better understand the disease's progression and treatment efficacy.

Why it matters

Where this research is happening

• Dana-Farber Cancer Inst
  Boston, United States Active

Researchers

• Principal investigator: Cutler, Corey S — Dana-Farber Cancer Inst
• Study coordinator: Cutler, Corey S

Related research

Other NIH-funded projects on the same topics.

• ChronicGVHD: How it happens and new ways to treat it

  A large NIH grant is funding research on chronic graft-versus-host disease after stem cell transplant, with a focus on the lungs and other organs, to improve outcomes for patients.

  NIH research Dana-Farber Cancer Inst · Boston, United States · NIH-11411246

• Propagation of GVHD through CD4+ T-cell recognition of gut bacteria

  Researchers are studying how a patient’s immune cells recognize gut bacteria after stem cell transplant to better understand and manage graft-versus-host disease.

  NIH research Fred Hutchinson Cancer Center · Seattle, United States · NIH-11377412

• How donor DNA affects immune responses in blood stem cell transplants

  This study is looking at how changes in donor DNA can help improve the success of stem cell transplants by boosting the body's ability to fight cancer while lowering the chances of complications, and it's aimed at helping patients who are getting these transplants.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11263108

• Understanding and treating chronic graft-versus-host disease and its lung form, bronchiolitis obliterans

  This project works to find new treatments that block immune and metabolic drivers of chronic GVHD and bronchiolitis obliterans in people after allogeneic stem cell transplant.

  NIH research Dana-Farber Cancer Inst · Boston, United States · NIH-11174465

• How donor DNA affects immune responses in blood stem cell transplants

  This study is looking at how changes in DNA from donor cells can affect the immune system during stem cell transplants, with the goal of finding better ways to help patients with serious cancers avoid complications while still fighting the disease.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11073092

• Understanding how Galectin-3 affects Graft vs. Host Disease and Graft vs. Tumor responses

  This study is looking at how a protein called Galectin-3 affects the immune responses in patients who have received a stem cell transplant, with the hope of finding ways to reduce complications like Graft vs. Host Disease and improve recovery.

  NIH research Roswell Park Cancer Institute Corp · Buffalo, United States · NIH-10857141

About this research

1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.