Improving glioma surgery and quality of life through personalized motor rehabilitation
Personalized Rendering of Motor System Functional Plasticity Potential to Improve Glioma Resection and Quality of Life
This study is testing if personalized motor rehab before surgery can help people with lower-grade gliomas have better surgery results and improve their quality of life.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 400 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | University of Milan Academic / other |
| Drugs / interventions | chemotherapy |
| Locations | 1 site (Milan, Lombardy) |
| Trial ID | NCT06381726 on ClinicalTrials.gov |
What this trial studies
This study aims to enhance the surgical outcomes for patients with lower-grade gliomas by fostering the brain's functional plasticity through pre-surgical motor rehabilitation and chemotherapy. By utilizing advanced neuroimaging techniques, the study will assess the potential for neural circuit reorganization that can improve the extent of tumor resection. Patients will undergo resting state functional MRI and receive tailored interventions to optimize their motor function before surgery. The ultimate goal is to increase progression-free survival and quality of life for these patients.
Who should consider this trial
Good fit: Ideal candidates are adults aged 18 and older with lower-grade gliomas involving motor pathways who are scheduled for surgery.
Not a fit: Patients under 18 years old or those unable to provide informed consent may not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could significantly improve surgical outcomes and quality of life for glioma patients.
How similar studies have performed: While the approach of enhancing neural plasticity is promising, this specific methodology is relatively novel and has not been extensively tested in prior studies.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria (ARM 1): * Patients signing informed consent for participation in the study * Males and females * Age ≥ 18 years * Patients with lower-grade gliomas with involvement of the motor pathways who are candidates for surgery Inclusion Criteria (ARM 2/3/4): * Patients signing informed consent for participation in the study * Males and females * Age ≥ 18 years * Patients with lower-grade gliomas treated over two years with tumors only biopsied and/or partially resected and eligible for second surgery Exclusion Criteria: * Age \<18 years * Inability to adhere to standard study controls * Subjects unable to understand and freely provide consent to the study
Where this trial is running
Milan, Lombardy
- IRCCS Ospedale Galeazzi Sant'Ambrogio — Milan, Lombardy, Italy (Recruiting)
Study contacts
- Principal investigator: Lorenzo Bello, MD — University of Milan
- Study coordinator: Lorenzo Bello, MD
- Email: lorenzo.bello@unimi.it
- Phone: 0039-340-217-1453
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.