Improving glioma surgery and quality of life through personalized motor rehabilitation
Official title: Personalized Rendering of Motor System Functional Plasticity Potential to Improve Glioma Resection and Quality of Life
Run by University of Milan · NCT06381726 · Data updated 2026-11-12
This study is testing if personalized motor rehab before surgery can help people with lower-grade gliomas have better surgery results and improve their quality of life.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 400 (estimated) |
| Sponsor | University of Milan Academic / other |
| Drugs / interventions | chemotherapy |
| Locations | 1 site (Milan, Lombardy) |
| Status | Recruiting |
| Started | March 7, 2024 |
| Main results expected | February 28, 2028 |
| Study ends | February 28, 2028 |
| Registry record updated | April 24, 2024 |
| Trial ID | NCT06381726 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are adults aged 18 and older with lower-grade gliomas involving motor pathways who are scheduled for surgery.
✕Probably not a fit
Patients under 18 years old or those unable to provide informed consent may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study aims to enhance the surgical outcomes for patients with lower-grade gliomas by fostering the brain's functional plasticity through pre-surgical motor rehabilitation and chemotherapy. By utilizing advanced neuroimaging techniques, the study will assess the potential for neural circuit reorganization that can improve the extent of tumor resection. Patients will undergo resting state functional MRI and receive tailored interventions to optimize their motor function before surgery. The ultimate goal is to increase progression-free survival and quality of life for these patients.
Why it matters
Potential benefit: If successful, this approach could significantly improve surgical outcomes and quality of life for glioma patients.
How similar studies have gone: While the approach of enhancing neural plasticity is promising, this specific methodology is relatively novel and has not been extensively tested in prior studies.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria (ARM 1): * Patients signing informed consent for participation in the study * Males and females * Age ≥ 18 years * Patients with lower-grade gliomas with involvement of the motor pathways who are candidates for surgery Inclusion Criteria (ARM 2/3/4): * Patients signing informed consent for participation in the study * Males and females * Age ≥ 18 years * Patients with lower-grade gliomas treated over two years with tumors only biopsied and/or partially resected and eligible for second surgery Exclusion Criteria: * Age \<18 years * Inability to adhere to standard study controls * Subjects unable to understand and freely provide consent to the study
Where it's running
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IRCCS Ospedale Galeazzi Sant'Ambrogio
Milan, Lombardy, Italy Recruiting
Study contacts
- Principal investigator: Lorenzo Bello, MD — University of Milan
- Study coordinator: Lorenzo Bello, MD
- Email: lorenzo.bello@unimi.it
- Phone: 0039-340-217-1453
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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This study is testing a new imaging method to see if it can help doctors better monitor and manage low-grade brain tumors in children.
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Using 18F-fluciclovine PET-MRI to assess high-grade gliomas in children
This study is testing a special imaging technique to see if it can help doctors tell the difference between real tumor growth and changes after treatment in children with high-grade brain tumors.
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YN003 injection in glioma patients
This phase 1 study tests whether YN003 injected IV is safe and tolerable for adults with recurrent or progressive glioma, and to explore how the drug behaves in the body and any early signs of activity.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.