Measuring mucosal impedance to diagnose gastroesophageal reflux disease

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to evaluate the role of mucosal impedance measurement in diagnosing gastroesophageal reflux disease (GERD), particularly in patients who have not responded adequately to proton pump inhibitors. It addresses the limitations of current diagnostic methods, such as upper gastrointestinal endoscopy and 24-hour impedance-pH monitoring, which may not provide sufficient sensitivity or specificity. By utilizing a minimally invasive device, the study seeks to improve diagnostic accuracy for patients with Non-Erosive Reflux Disease (NERD) and enhance treatment strategies based on accurate diagnoses.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patients \>18 years presenting symptoms of GERD that have not adequately responded to proton pump inhibitors (PPIs) treatment after 8 weeks and have undergone upper gastrointestinal endoscopy (UGIE) without erosive esophagitis.

Patients with a broad spectrum of severity, assessed through the GERDq score, will be included

Exclusion Criteria:

* ● Pregnancy or lactation

  * Esophageal disorders (esophageal motor disorders, eosinophilic esophagitis, neoplastic diseases)
  * Uncontrolled systemic diseases (diabetes mellitus, hypo- or hyperthyroidism, cancer, etc.)
  * Lack of informed consent
  * Severe psychiatric disorders

Where it's running

• Hospital de Clinicas
  Buenos Aires, Argentina Recruiting

Study contacts

• Principal investigator: Jorge a Olmos, Md — Hospital de Clinicas Jose de San Martin
• Study coordinator: Maria M Piskorz, Md
• Email: neurogastrohc@gmail.com
• Phone: 5491133192885

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.