Assessing esophageal motility after partial fundoplication for reflux

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study evaluates patients who have undergone or are scheduled for laparoscopic partial fundoplication to treat gastroesophageal reflux. It aims to assess preoperative ineffective esophageal motility and hypothesizes that these motility disorders are caused by reflux. Postoperative high-resolution manometry will be used to determine changes in esophageal motility. The study also examines secondary endpoints, including the presence of new motility disorders and gastrointestinal symptoms before and after surgery.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age older than 18 years
* Ineffective esophageal motility disorder according the Chicago classification (7), defined as ≥ 7/10 (70%) of swallows with weak contraction (distal contraction interval (DCI) between 100mmHg/s/cm and less than 450 mmHg/s/cm) or ≥ 5/10 (50%) of swallows with failed peristalsis (DCI \<100mgHg/s/cm)Performance of partial fundoplication (180° anterior or 270° posterior) at Spital Limmattal
* Informed Consent as documented by signature

Exclusion Criteria:

* Age under 18 years
* Pregnancy
* Normal preoperative esophageal motility
* Other specifically defined esophageal motility disorders such as Nutcracker or Jackhammer esophagus
* Preoperative presence of a hiatal hernia with migration of \>20% of stomach in the chest
* Revisional surgery (after other procedures for reflux or at the hiatus)

Where it's running

• Spital Limmattal
  Schlieren, Canton of Zurich, Switzerland Recruiting

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.