Project to improve detection of Barrett's Esophagus and related neoplasia
Official title: Endoscopic Detection of Early Neoplasia in Patients With Barrett's Esophagus
Run by Midwest Veterans' Biomedical Research Foundation · NCT00590239 · Data updated 2026-11-12
This study is testing new ways to better detect Barrett's esophagus and early signs of cancer to help improve care for patients with this condition.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 150 (estimated) |
| Sponsor | Midwest Veterans' Biomedical Research Foundation Academic / other |
| Locations | 1 site (Kansas City, Missouri) |
| Status | Recruiting |
| Started | May 15, 2007 |
| Main results expected | November 1, 2026 |
| Study ends | December 30, 2026 |
| Registry record updated | November 22, 2024 |
| Trial ID | NCT00590239 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this project are adults aged 18-80 who are undergoing endoscopy for screening or surveillance of Barrett's esophagus or for treatment of early mucosal neoplasia.
✕Probably not a fit
Patients with significant co-morbid conditions that prevent safe administration of conscious sedation or those unable to provide informed consent may not benefit from this project.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This project focuses on enhancing the detection rates of Barrett's esophagus and early neoplasia using advanced endoscopic techniques such as high resolution endoscopy, narrow band imaging, and chromoendoscopy. It aims to create a video-atlas of lesions for training purposes and to establish a standardized classification system for mucosal and vascular patterns observed in Barrett's esophagus. The project will also evaluate the interobserver agreement on these classifications and assess the endoscopic detection rates of esophageal cancer or precancerous lesions. Ultimately, it seeks to improve clinical outcomes for patients with Barrett's esophagus.
Why it matters
Potential benefit: If successful, this project could lead to earlier detection and treatment of esophageal cancer, potentially reducing mortality rates associated with this condition.
How similar studies have gone: Other studies utilizing advanced endoscopic techniques have shown promise in improving detection rates of Barrett's esophagus and related neoplasia, indicating that this approach is supported by prior research.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * 18-80 years * Patients must be able to provide written informed consent * Patients referred for endoscopy for screening/surveillance of BE or for endoscopic treatment of BE with early mucosal neoplasia Exclusion Criteria: * Current use of aspirin, non-steroidal anti-inflammatory agents(NSAIDs),or chronic anticoagulants that cannot be discontinued prior to the procedure. * Inability to provide written informed consent * Significant thrombocytopenia or coagulopathy * Any significant co-morbid condition that would prevent the safe administration of conscious sedation
Where it's running
-
Kansas city VA Medical center
Kansas City, Missouri, United States Recruiting
Study contacts
- Principal investigator: Prateek Sharma, MD — Kansas City VA Medical Center
- Study coordinator: April Higbee, BN
- Email: April.Higbee@va.gov
- Phone: 8168614700
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.