Predicting gastroesophageal reflux after sleeve gastrectomy

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to identify predictors for gastroesophageal reflux disease (GERD) following sleeve gastrectomy. Participants will undergo an upper endoscopy with the EndoFLIP device before the surgery to gather data on various parameters. A follow-up endoscopy will be conducted at six months post-surgery if clinically indicated, along with questionnaires over a five-year period to assess outcomes. The goal is to develop a predictive model for GERD after the procedure.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Adult patients \> 18 years
* BMI 30 or greater kg/m2
* Participants can give a consent to the procedure
* Participants have no contraindications to LSG (gastric ulceration)

Exclusion Criteria:

* Participants who have LA grade C or D esophagitis, Barrett mucosa or peptic stricture.
* Patients who have evidence of a major motility abnormality defined by the Chicago classification version 3.0 (achalasia, absent contractility, esophagogastric junction outflow obstruction, distal esophageal spasm, or hypertensive peristalsis)
* Patients with hiatal hernia \> 3 cm
* Patients with previous esophageal or stomach surgery

Where it's running

• Mayo Clinic in Rochester
  Rochester, Minnesota, United States Recruiting
• Orlando Health
  Orlando, Florida, United States Active not recruiting

Study contacts

• Principal investigator: Omar Ghanem, MD — Mayo Clinic
• Study coordinator: Elizabeth Lemke
• Email: Lemke.Elizabeth@mayo.edu
• Phone: 5072663317

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• 15-year outcomes after sleeve gastrectomy in France

  This study looks at how people who had sleeve gastrectomy have fared over 15 years to see long-term weight changes and health effects.

  Recruiting Centre Hospitalier Universitaire, Amiens · Amiens · NCT07883018

• POEM vs Heller myotomy with Dor fundoplication for achalasia

  This trial tests POEM against laparoscopic Heller myotomy with Dor fundoplication to see which procedure better helps adults with achalasia.

  Recruiting Minia University · Minya, Minya Governorate · NCT07814027

• Extra daily iron after sleeve gastrectomy to prevent anemia

  This study tests whether taking an extra daily iron pill plus a multivitamin prevents iron deficiency anemia in adults during the six months after sleeve gastrectomy compared with taking a multivitamin alone.

  Recruiting Cairo University · Cairo, Al-Manial Cairo · NCT07397572

• Foot reflexology to reduce nausea after sleeve gastrectomy

  This will try foot reflexology to see if it reduces nausea and vomiting in adults after sleeve gastrectomy.

  Recruiting Centre Hospitalier Departemental Vendee · La Roche-sur-Yon · NCT07313293

• Hydrotalcite (Talcid) for relief of rebound acid symptoms after stopping long-term PPI therapy

  We are trying hydrotalcite (Talcid) to see if it relieves rebound acid symptoms in adults who have stopped long-term PPI treatment.

  Recruiting Bayer · Multiple Locations · NCT07291700

• Digestion and gut function after bariatric surgery

  This project will test how digestion — including enzymes, bile acids, pH, and transit time — works in adults with obesity and in people at least one year after Roux‑en‑Y or sleeve gastrectomy by collecting intestinal samples and using a swallowable sensor capsule.

  Recruiting Universitaire Ziekenhuizen KU Leuven · Leuven · NCT07286968

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.