Breath testing for small intestinal bacterial overgrowth after proton pump inhibitors

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to investigate the prevalence of small intestinal bacterial overgrowth (SIBO) in patients experiencing gastroesophageal reflux symptoms who have been treated with proton pump inhibitors (PPIs). Participants will undergo breath testing to assess the presence of SIBO following their PPI treatment. The study seeks to provide insights into the relationship between PPI use and the occurrence of SIBO, which may have implications for managing gastroesophageal reflux disease. By understanding this connection, researchers hope to improve treatment strategies for affected patients.

Why it matters

Who can join: the full rules

Inclusion criteria:

* Predominant symptoms of gastroesophageal reflux disease including heartburn, regurgitation
* Subjects must be able to give appropriate informed consent

Exclusion criteria:

* Prior diagnosis of SIBO
* Use of PPIs or H2R-anatagonstists in the prior 3 months
* Major concomitant illness (renal, hepatic, rheumatologic or cardiovascular disease, or malignancy)
* Antibiotic therapy within one month
* Prior gastrointestinal surgery including esophageal, gastric, and small or large bowel surgery
* Previously diagnosed irritable bowel syndrome or inflammatory bowel disease
* Individuals who are pregnant or breast feeding
* Patients with plans to become pregnant
* Inability to take PPIs, including allergy/sensitivity

Where it's running

• Mayo Clinic Florida
  Jacksonville, Florida, United States Recruiting

Study contacts

• Principal investigator: Andree Koop, MD — Mayo Clinic

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.