Condition

Barrett Esophagus clinical trials and research

• 26Clinical trials
• 9Countries

Newest Barrett Esophagus clinical trials

All recruiting trials (26)

• Predictors of symptom improvement after laparoscopic fundoplication

  This study tests what preoperative factors help predict which GERD patients will feel better after laparoscopic fundoplication.

  Recruiting Minia University · Minya, Minya Governorate · NCT07809620

• Potassium-Competitive Acid Blockers in Barrett’s Esophagus on PPI Therapy

  This study tests whether vonoprazan, a potassium-competitive acid blocker, can better reduce acid reflux in adults with nondysplastic Barrett’s esophagus who are already taking a daily PPI.

  Recruiting Phase 4 University of North Carolina, Chapel Hill · Chapel Hill, North Carolina · NCT07788742

• How radiofrequency ablation affects esophagus stretchiness and mucosal impedance

  This study will test whether radiofrequency ablation changes how stretchy the esophagus is and the mucosal impedance in adults treated for dysplastic Barrett's esophagus.

  Recruiting Mayo Clinic · Rochester, Minnesota · NCT07126535

• Detecting Barrett's Esophagus with a Non-Endoscopic Device

  This study is testing a new capsule device that collects cells from the esophagus to see if it can effectively detect Barrett's Esophagus in people at high risk, without needing an endoscopy.

  Recruiting Cyted Health Inc · Cordova, Tennessee · NCT06803927

• Stopping routine endoscopic surveillance for low-risk Barrett's esophagus (BLISS Project)

  This project will try stopping routine endoscopies in people with low-risk, non-dysplastic Barrett's esophagus to see if it remains safe.

  Recruiting Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) · Amsterdam · NCT06803147

• Non-endoscopic test to find Barrett's esophagus in veterans without chronic reflux.

  This project will test whether a simple, non-endoscopic swab-like test can find Barrett's esophagus in veterans over 40 who have risk factors for esophageal cancer but no chronic heartburn.

  Recruiting Louis Stokes VA Medical Center · Cleveland, Ohio · NCT06746623

• Itraconazole with endoscopic ablation to prevent esophageal cancer in high‑risk Barrett's esophagus

  This study tests if adding itraconazole to the standard endoscopic ablation can better prevent esophageal cancer in people with high-risk Barrett's esophagus.

  Recruiting at 4 sites Phase 2 National Cancer Institute (NCI) · Kansas City, Kansas and 5 other locations · NCT06732388

• Capsule-sponge surveillance for ultralong-segment Barrett's esophagus

  This tests whether the EndoSign capsule-sponge can detect precancerous changes and early esophageal cancer in adults with ultralong-segment Barrett's esophagus compared with standard endoscopy.

  Recruiting Erasmus Medical Center · Rotterdam, South Holland · NCT06720636

• Understanding patient preferences for screening tests for Barrett's esophagus and esophageal cancer

  This study is trying to understand what patients prefer when it comes to screening tests for Barrett's esophagus and esophageal cancer to help improve current practices.

  Recruiting University of Colorado, Denver · Aurora, Colorado · NCT06693622

• Detecting Barrett's Esophagus in Patients Without GERD Symptoms

  This study is testing a new way to find Barrett's esophagus in people who don’t have GERD symptoms by using a simple capsule test instead of the usual endoscopy.

  Recruiting at 5 sites Case Comprehensive Cancer Center · Aurora, Colorado and 4 other locations · NCT06687603

• Assessing Barrett's Esophagus in Patients with Anorexia Nervosa and Purging Behaviors

  This study is trying to see if people with anorexia nervosa who purge have Barrett's esophagus, using non-invasive tests to check for this condition in patients aged 18-65.

  Recruiting at 3 sites Denver Health and Hospital Authority · Denver, Colorado and 2 other locations · NCT06532734

• Assessing breath and blood biomarkers for early detection of gastro-esophageal cancer

  This study is testing if breath and blood samples can help find early signs of gastro-esophageal cancer in people who are at risk.

  Recruiting KU Leuven · Leuven · NCT06346054

• Using a swallowable sponge to collect esophageal samples for Barrett's esophagus detection

  This study is testing a swallowable sponge to see if it can safely collect samples from the esophagus to help detect Barrett's esophagus and esophageal cancer in patients who may have these conditions.

  Recruiting at 3 sites Mayo Clinic · Scottsdale, Arizona and 4 other locations · NCT06071845

• Registry for patients undergoing esophageal cancer screening

  This study is collecting information from patients getting screened for Barrett Esophagus and Esophageal Adenocarcinoma using a new test to see how well it works and how patients feel about the process.

  Recruiting PAVmed Inc. · Lake Forest, California · NCT05965999

• Comparing surveillance and therapy for Barrett's esophagus with low-grade dysplasia

  This study is testing whether regular check-ups or a treatment to remove precancerous cells is better for people with Barrett's esophagus and low-grade dysplasia.

  Recruiting at 28 sites University of Colorado, Denver · Birmingham, Alabama and 29 other locations · NCT05753748

• Comparing biopsy methods for monitoring Barrett's Esophagus

  This study is testing whether a new biopsy method called WATS is better than the usual random biopsies for monitoring patients with Barrett's Esophagus who are at high risk for serious complications.

  Recruiting Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) · Amsterdam, North Holland · NCT05642338

• Comparing two methods for sampling Barrett's esophagus

  This study is testing which method, the standard biopsy or a new sampling technique, is better at finding early signs of cancer in people with Barrett's esophagus.

  Recruiting at 14 sites University of Colorado, Denver · Gilbert, Arizona and 13 other locations · NCT05530343

• Evaluating outcomes of endoscopic submucosal dissection for gastrointestinal lesions

  This study is trying to see how well a new technique called endoscopic submucosal dissection works for removing gastrointestinal lesions in patients, especially in the esophagus and colon, compared to older methods.

  Recruiting AdventHealth · Orlando, Florida · NCT05468008

• Collecting data to predict cancer risk in at-risk populations

  This study is trying to collect samples and health information from people at higher risk of cancer to see if they can find signs that help predict cancer early on.

  Recruiting Dana-Farber Cancer Institute · Boston, Massachusetts · NCT05463796

• Long-term saliva sampling for Barrett's esophagus

  This study is testing if regular saliva samples can help identify a specific oral bacteria pattern in people with Barrett's esophagus to see if it can be used as a simple way to diagnose this condition.

  Recruiting at 2 sites Columbia University · Ann Arbor, Michigan and 1 other locations · NCT05133102

• Using obeticholic acid to prevent progression in Barrett's esophagus

  This study is testing if the medication obeticholic acid can help prevent Barrett's esophagus from getting worse in people at risk of developing esophageal cancer.

  Recruiting at 6 sites Phase 2 National Cancer Institute (NCI) · Kansas City, Kansas and 7 other locations · NCT04939051

• Comparing EndoRotor and Radiofrequency for Barrett's Esophagus treatment

  This study is testing whether a new treatment called EndoRotor works better than radiofrequency for people with Barrett's esophagus and dysplasia.

  Recruiting at 11 sites University Hospital, Angers · Besançon and 16 other locations · NCT04867590

• Registry to evaluate biopsy methods for esophageal conditions

  This study is trying to see how two different biopsy methods during endoscopy can help doctors make better treatment decisions for patients with esophageal conditions.

  Recruiting CDx Diagnostics · Bethpage, New York · NCT04312633

• Detecting early esophageal cancer using sponge cytology

  This study is testing if a sponge can help find early signs of esophageal cancer and Barrett's Esophagus in people having an endoscopy at Johns Hopkins Hospital.

  Recruiting at 2 sites Johns Hopkins University · Baltimore, Maryland and 1 other locations · NCT04214119

• New technology for capturing tissue samples in Barrett's Esophagus patients

  This study is testing a new capsule that patients swallow to take pictures of their esophagus and capture tissue samples to see if it can better identify risks for cancer in people with Barrett's Esophagus.

  Recruiting Massachusetts General Hospital · Boston, Massachusetts · NCT03830801

• Endoscopic follow-up for patients with esophageal adenocarcinoma

  This study is testing if a less invasive follow-up method using endoscopy is safe for patients who have had surgery for certain types of esophageal adenocarcinoma.

  Recruiting at 19 sites Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) · Sydney and 19 other locations · NCT03222635

Related topics

Quick answers

How many Barrett Esophagus clinical trials are recruiting right now?

26, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 9 countries. The most sites are in United States (19 trials), Netherlands (4 trials), Belgium (2 trials), Australia (1 trial), Germany (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 2, Phase 4: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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