Understanding and treating a specific type of brain tumor caused by a gene fusion
Official title: Biology and therapy of C11orf95-RELA fusion-driven ependymoma
Funded at Fred Hutchinson Cancer Center · NIH-10603048 · Data updated 2026-11-12
This study is looking at a specific kind of brain tumor called ependymoma, which is linked to a gene fusion, and aims to understand how this tumor grows and find new ways to treat it, using advanced lab techniques and models.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Fred Hutchinson Cancer Center NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project start | September 19, 2019 |
| Project end | August 31, 2025 |
| Funding year | 2019 |
| Award (this year) | $1,092,169 |
| NIH project number | 6U54CA243125-02 |
| Project ID | NIH-10603048 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients diagnosed with supratentorial ependymoma that express the C11orf95-RELA fusion.
✕Less likely to help
Patients with other types of brain tumors or those without the C11orf95-RELA fusion may not benefit from this research.
What this research studies
This research focuses on a type of brain tumor known as ependymoma, specifically those driven by a gene fusion called C11orf95-RELA. The team aims to explore the biology of this fusion protein and identify the critical pathways involved in tumor growth. They will utilize advanced mouse models and human neuro stem cell systems to analyze the tumor's characteristics at a single-cell level. The research includes identifying potential therapeutic vulnerabilities and testing small molecules that may effectively treat this type of tumor.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for patients with C11orf95-RELA fusion-driven ependymoma.
How similar studies have gone: Other research has shown promise in targeting gene fusions in cancer, suggesting that this approach could lead to significant advancements in treatment.
Where this research is happening
-
Fred Hutchinson Cancer Center
Seattle, United States Active
Researchers
- Principal investigator: Holland, Eric C. — Fred Hutchinson Cancer Center
- Study coordinator: Holland, Eric C.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.