Understanding how a specific gene fusion drives a type of childhood brain cancer.
Transcriptional Regulation in ZFTA-RELA Ependymoma
This study is looking at how a specific gene change might help cause ependymoma, a type of brain cancer in kids, and aims to find new ways to treat it by understanding how this change affects tumor growth.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | St. Jude Children's Research Hospital NIH-funded |
| Lab location | 1 site (Memphis, United States) |
| Project ID | NIH-10892870 on NIH RePORTER |
What this research studies
This research investigates the role of a gene fusion between ZFTA and RELA in the development of ependymoma, a serious form of pediatric brain cancer. By using a specialized mouse model, the researchers aim to uncover how this genetic alteration affects the transcriptional networks that contribute to tumor growth and progression. The study focuses on identifying key transcription factors involved in this process, which could lead to new treatment strategies for affected children. Patients may benefit from insights gained into the mechanisms of their cancer, potentially leading to more effective therapies.
Who could benefit from this research
Good fit: Ideal candidates for this research are children diagnosed with ependymoma or those at risk due to genetic factors.
Not a fit: Patients with other types of brain tumors or those not affected by ependymoma may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatment options for children with ependymoma by targeting the underlying genetic mechanisms of the disease.
How similar studies have performed: Previous research has shown promise in targeting genetic alterations in other cancers, suggesting that this approach may yield valuable insights for ependymoma as well.
Where this research is happening
Memphis, United States
- St. Jude Children's Research Hospital — Memphis, United States (Active)
Researchers
- Principal investigator: Mack, Stephen C — St. Jude Children's Research Hospital
- Study coordinator: Mack, Stephen C
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.