Condition

Dry Eye Disease clinical trials and research

• 10Clinical trials
• 16NIH research projects
• 1New in 30 days
• 8Countries

Newest Dry Eye Disease clinical trials

All recruiting trials (10)

• See if TRYPTYR 0.003% helps dry eye symptoms and signs

  This study tests whether acoltremon 0.003% can improve symptoms and eye findings in adults with dry eye disease.

  Recruiting at 2 sites Scott & Christie and Associates, PC · Scottsdale, Arizona and 1 other locations · NCT07926594

• BL1107 dosing for drying eye redness: finding the lowest effective amount

  This trial tests whether different doses of BL1107 can fully reduce conjunctival redness in people with dry eye disease, while keeping participants unaware of the dose they receive.

  Recruiting Phase 2 Bausch & Lomb Incorporated · Newport Beach, California · NCT07778888

• Eye drops from umbilical cord stem cell vesicles to help dry eye

  A tiny drop of human umbilical cord stem cell–derived vesicles is applied to the eye daily for four weeks to see if it helps dry eye symptoms and signs.

  Recruiting Early Phase 1 The First Affiliated Hospital of Xiamen University · Xiamen, China · NCT07623382

• Tear iron levels and dry eye severity

  This project will see if the amount of iron in tears is linked to how severe someone's dry eye is by comparing people with dry eye to healthy volunteers.

  Recruiting Shanghai Changzheng Hospital · Shanghai · NCT07363824

• Vitamin A–based eye ointment for dry, burning, or irritated eyes

  This trial will try a vitamin A–based ointment called Vit-A-Vision in adults with dry eye symptoms to see if it improves comfort and tear stability.

  Recruiting OmniVision GmbH · Cologne · NCT06596733

• Exploring dry eye disease patterns after cataract surgery

  This study looks at how cataract surgery affects dry eye symptoms in patients aged 50 to 90 and tests if using artificial tears helps improve their comfort over time.

  Recruiting Lithuanian University of Health Sciences · Kaunas · NCT06298890

• Comparing BUFY02 and TRB02 eye drops for dry eye disease

  This test will see if BUFY02 eye drops work as well as TRB02 eye drops to improve signs and symptoms for adults with dry eye disease when used daily for three months.

  Recruiting at 6 sites TRB Chemedica International SA · Graz and 5 other locations · NCT05865457

• BUFY01 versus SVS20 eye drops for dry eye disease

  We will test whether BUFY01 eye drops work as well as SVS20 eye drops to improve signs and symptoms in adults with dry eye disease.

  Recruiting at 3 sites TRB Chemedica International SA · Leuven and 2 other locations · NCT05865379

• Identifying treatment targets and biomarkers for dry eye disease in cancer patients

  This study is trying to learn more about eye problems in cancer patients, especially those with a specific condition, by looking at their eyes over time and comparing them to healthy individuals.

  Recruiting University of Maryland, Baltimore · Baltimore, Maryland · NCT04946721

• Exploring the link between the eye's microbiome and immune system in dry eye disease

  This study looks at the eye's bacteria and immune system in people with and without dry eye disease to see how they might be connected and what could help improve symptoms.

  Recruiting Insel Gruppe AG, University Hospital Bern · Bern · NCT04658238

NIH-funded research (16)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Stabilizing the tear film to relieve evaporative dry eye

  This project tests new ways to stabilize the tear film in people with evaporative dry eye, with the goal of longer-lasting comfort.

  NIH research Michigan State University · East Lansing, United States · NIH-11641969

• A new way to understand evaporative dry eye

  Researchers are building a lab model to better understand why people develop evaporative dry eye so treatments can be improved.

  NIH research Michigan State University · East Lansing, United States · NIH-11398342

• Mitigating Dry Eye Symptoms by Improving Indoor Air Quality

  Aimed at adults with dry eye symptoms, this study tests a low-cost, multi-faceted plan to improve indoor air and reduce eye discomfort.

  NIH research University of Miami School of Medicine · Coral Gables, United States · NIH-11344220

• Tear microRNA patterns in women and men with dry eye

  Researchers will look at tiny RNA molecules in tear fluid from people with dry eye to find patterns linked to sex and race.

  NIH research Augusta University · Augusta, United States · NIH-11311871

• Immune causes of chronic dry eye

  This work looks at how certain immune cells make dry eye persist in adults and aims to point toward better, longer-lasting treatments.

  NIH research Schepens Eye Research Institute · Boston, United States · NIH-11237037

• A new type of plug to help relieve dry eye symptoms

  This study is working on a new type of eye plug that can help make life easier for people with dry eyes by using special materials that adjust to their needs, aiming to provide more comfort and better results than current treatments.

  NIH research Aesculatech, INC. · Los Angeles, UNITED STATES · NIH-11216481

• Preventing dry eye disease and age-related Meibomian gland dysfunction

  This study is looking at how changing the support structure around eye glands might help prevent dry eye and related issues as we age, and it aims to find new ways to help people who struggle with dry eyes.

  NIH research University of Houston · Houston, United States · NIH-11160450

• Why dry eye gets worse in autoimmune disease

  Researchers are mapping the different cell types in the cornea and how they change in people with autoimmune-related dry eye to help find ways to protect the eye and relieve symptoms.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11138650

• Investigating tear fluid differences in dry eye disease based on sex and race

  This study is looking at dry eye disease to find out how certain tiny molecules in your tears can help us understand the condition better and create personalized treatments, especially for women and specific racial groups who may be more affected.

  NIH research Augusta University · Augusta, United States · NIH-11117178

• Developing a new treatment for dry eye disease caused by Sjogren's syndrome

  This study is testing a new, easy-to-get treatment for dry eyes caused by Sjogren's syndrome, using special cells to create a healing extract that could help improve your symptoms and overall eye health.

  NIH research Stellular Bio, INC. · Watertown, United States · NIH-11067525

• Understanding how dry eye disease progresses

  This study is looking into how dry eye disease gets worse in people with autoimmune conditions like Sjögren's syndrome and rheumatoid arthritis, to help find better ways to manage the symptoms by understanding the changes happening in the eye.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11046163

• Understanding evaporative dry eye disease and its causes

  This study is looking at dry eye disease by using special mice that have a gene missing, which helps researchers learn more about what causes this common eye problem and how we might be able to treat it better in people.

  NIH research University of California at Davis · Davis, United States · NIH-11039647

• Understanding tear film stability to create new treatments for dry eye disease

  This study is looking at how to make tears last longer for people with dry eye by exploring a special ingredient found in rabbit tears that could help improve tear stability, with the hope of creating a new treatment that brings better relief for those suffering from evaporative dry eye disease.

  NIH research University of California at Davis · Davis, United States · NIH-10983731

• Exploring how social factors affect access to eye care for dry eye disease

  This study looks at how factors like race, ethnicity, and language affect people's access to eye care and their experiences with dry eye disease, aiming to find ways to improve treatment and support for patients over the next two years.

  NIH research University of Colorado Denver · Aurora, UNITED STATES · NIH-10950592

• Understanding how dry eye disease progresses

  This study is looking into how dry eye disease, especially when connected to autoimmune issues like Sjögren's syndrome and rheumatoid arthritis, affects the cells in your eyes, with the hope of finding new ways to help manage the condition.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-10898842

• Investigating the role of the immune system in dry eye disease linked to Sjögren's syndrome

  This study is looking at how the immune system affects dry eye disease in people with Primary Sjögren's syndrome, with the goal of finding new ways to identify and treat this condition to help improve eye health and comfort.

  NIH research University of Alabama at Birmingham · Birmingham, United States · NIH-10561638

Related topics

Quick answers

How many Dry Eye Disease clinical trials are recruiting right now?

10, as of November 12, 2026. 1 of them was first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 8 countries. The most sites are in United States (3 trials), China (2 trials), France (2 trials), Switzerland (1 trial), Germany (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Early Phase 1: 1, Phase 2: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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