Investigating genetic similarities between primary colorectal tumors and their brain metastases
Comparison of Molecular-Genetic Concordance of the Primary Tumor and Brain Metastases of Colorectal Cancer
This study is looking at the genetic similarities between original colorectal cancer tumors and their brain metastases to see how closely they match in terms of important gene mutations.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 30 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Blokhin's Russian Cancer Research Center Academic / other |
| Locations | 1 site (Moscow, Moscow) |
| Trial ID | NCT06449989 on ClinicalTrials.gov |
What this trial studies
This observational study aims to analyze the molecular genetic profiles of primary colorectal cancer tumors and their corresponding brain metastases. By examining tumor samples from patients who have undergone neurosurgical resection, the study will assess the mutation status of key genes including KRAS, NRAS, BRAF, and HER2. The goal is to determine the concordance rate of these mutations between the primary tumors and brain metastases, which could provide insights into the biology of metastatic colorectal cancer. The research is based on a retrospective analysis of a limited number of patient samples collected over 26 years.
Who should consider this trial
Good fit: Ideal candidates include adults over 18 with histologically confirmed colorectal cancer and brain metastases who have undergone neurosurgical resection.
Not a fit: Patients without paired tumor samples or those with low-quality tumor material may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could enhance understanding of colorectal cancer metastasis to the brain, potentially leading to improved treatment strategies.
How similar studies have performed: While studies on colorectal cancer metastasis exist, this specific investigation into the genetic concordance of primary tumors and brain metastases is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Men and women over 18 years of age. 2. Histologically confirmed cancer of the colon or rectum. 3. Histologically confirmed metastatic lesion of the brain. 4. Neurosurgical resection for brain metastases of colorectal cancer. 5. Presence of paired tumor samples (both primary tumor and intracranial material). Exclusion Criteria: 1. Missing one sample from a pair of tumor samples. 2. Low quality or lack of tumor material for molecular genetic research.
Where this trial is running
Moscow, Moscow
- Blokhin's Russian Cancer Research Center — Moscow, Moscow, Russia (Recruiting)
Study contacts
- Study coordinator: David Halafyan, MD
- Email: daveupnow@gmail.com
- Phone: +7(930)928-00-72
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.