Combining chemotherapy and immunotherapy for advanced colorectal cancer treatment

Efficacy and Safety of Chemotherapy With XELOX (Oxaliplatin + Capecitabine) and Bevacizumab in Combination With Adebrelimab in First-line Treatment of Microsatellite Stable (MSS) Initially Unresectable Metastatic Colorectal Cancer: a Prospective, Multicenter, Single-arm Study

This study is testing a new combination of chemotherapy and immunotherapy to see if it helps people with advanced colorectal cancer live longer and feel better.

Quick facts

• Phase: PHASE2
• Study type: Interventional
• Enrollment: 36 (estimated)
• Ages: 18 Years to 75 Years
• Sex: All
• Sponsor: The Fourth Affiliated Hospital of Zhejiang University School of Medicine (other)
• Drugs / interventions: fuquintinib, chemotherapy, immunotherapy, Bevacizumab, Adebrelimab, attillizumab, adbelizumab
• Locations: 1 site (Jinhua, Zhejiang)
• Trial ID: NCT06282445 on ClinicalTrials.gov

What this trial studies

This study evaluates the efficacy and safety of a combination treatment involving XELOX chemotherapy (oxaliplatin and capecitabine) and bevacizumab, along with the immunotherapy drug adebrelimab, for patients with microsatellite stable (MSS) initially unresectable metastatic colorectal cancer. The aim is to improve survival outcomes for patients who currently have limited treatment options and a short expected survival time. Participants will be monitored for treatment response and adverse effects to determine the overall effectiveness of this new regimen compared to standard treatments.

Who should consider this trial

Good fit: Ideal candidates are adults aged 18-75 with histologically confirmed metastatic colorectal cancer that is initially unresectable and microsatellite stable.

Not a fit: Patients with resectable metastatic colorectal cancer or those outside the specified age range may not benefit from this study.

Why it matters

Potential benefit: If successful, this treatment could significantly extend survival and improve quality of life for patients with advanced colorectal cancer.

How similar studies have performed: Previous studies have shown promising results with similar combinations of chemotherapy and immunotherapy, indicating potential for success in this approach.

Eligibility criteria

Inclusion Criteria:

* 1.The patients voluntarily participated in the study, signed the informed consent, and had good compliance.
* 2\. Age 18-75 years (including 18 and 75) .
* 3\. Metastatic colorectal cancer confirmed histologically and/or cytologically and initially unresectable.
* 4.MSS or pMMR.
* 5.Patients must have at least one measurable lesion (RECIST 1.1).
* 6.ECOG physical condition 0-1 score.
* 7.Expected survival ≥12 weeks.
* 8.Blood examination (no blood transfusion within 14 days, no correction of granulocyte colony stimulating factor or other hematopoietic stimulating factor within 7 days before laboratory examination).

  1. neutrophil absolute value ≥1.5×109/L, platelets ≥100×109/L, hemoglobin concentration ≥9g/dL)
  2. Liver function test (bilirubin ≤1.5×ULN; Aspartate aminotransferase and glutamic acid aminotransferase ≤2.5×ULN, AST and ALT≤5×ULN in the case of liver metastasis);
  3. Renal function (serum creatinine ≤1.5×ULN, or creatinine clearance (CCr)≥60ml/min);
  4. Coagulation, International standardized ratio (INR) ≤1.5×ULN, prothrombin time (PT) and activated partial thromboplastin time (APTT) ≤1.5×ULN;
  5. Thyroid function, thyroid stimulating hormone (TSH) ≤ the upper limit of normal (ULN); If there is any abnormality, FT3 and FT4 levels should be examined. If FT3 and FT4 levels are normal, they can be selected.
* 9.Reproductive-age women must have a negative serum pregnancy test within 14 days before treatment and be willing to use a medically acceptable effective contraceptive method (e.g., an intrauterine device, oral contraceptives, or condoms) during the study and for 3 months after the last study dose; for male subjects who are married to a reproductive-age woman, surgical sterilization is required or effective contraception is recommended during the study and for 3 months after the last study dose.

Exclusion Criteria:

* 1.Received the following treatments within 4 weeks prior to treatment: radiotherapy for tumors, surgery, chemotherapy, immunotherapy or molecular targeted therapy, or other investigational medications.
* 2.Active autoimmune disease requiring systemic therapy (i.e., disease-modifying drugs, corticosteroids, or immunosuppressants) has been used within the past 2 years. Replacement therapies (such as thyroxine, insulin, or physiologic corticosteroid replacement for adrenal or pituitary insufficiency) are not considered systemic therapy.
* 3.Diagnosed with an immune deficiency within 7 days prior to the first treatment or received systemic steroid therapy or any other form of immunosuppressive therapy. The use of physiological doses of corticosteroids may be approved after consultation with the sponsor.
* 4.Previously received anti-vascular small-molecule targeted drug therapy, such as fuquintinib.
* 5.Previous treatment with irinotecan based chemotherapy regimens.
* 6.Symptomatic brain or meningeal metastasis.
* 7.RAS wild-type left half colon cancer.
* 8.Metastatic colorectal cancer with MSI-H or dMMR.
* 9.Severe infection (such as intravenously administered antibiotics, antifungals, or antivirals) within 4 weeks of treatment, or unexplained fever \> 38.5 ° C during screening/first administration.
* 10.Have high blood pressure that is not well controlled with antihypertensive medications (systolic blood pressure ≥140 mmHg or diastolic blood pressure ≥90 mmHg).
* 11.There were obvious clinical bleeding symptoms or obvious bleeding tendency within 3 months before treatment (bleeding \> 30 mL within 3 months, hematemesis, black stool, blood in the stool), hemoptysis (\> 5 mL of fresh blood within 4 weeks), etc. Or treatment of venous/venous thrombosis events within the preceding 6 months, such as cerebrovascular accidents (including transient ischemic episodes, cerebral hemorrhage, cerebral infarction), deep vein thrombosis, and pulmonary embolism; Long-term anticoagulant therapy with warfarin or heparin, or long-term antiplatelet therapy (aspirin ≥300 mg/day or clopidogrel ≥75 mg/day) is required.
* 12.During screening, it was found that the tumor invaded large vascular structures, such as pulmonary artery, superior vena cava or inferior vena cava, etc., and the researchers judged that there was a risk of major bleeding.
* 13.Active heart disease, including myocardial infarction, severe/unstable angina, occurred 6 months before treatment. Left ventricular ejection fraction \<50% by echocardiography showed poor arrhythmia control.
* 14.Patients have had other malignancies (except cured basal cell carcinoma of the skin and cervical carcinoma in situ) within the previous 5 years or at the same time.
* 15.Is known to be allergic to the investigational drug or any of its excipients.
* 16.Active or uncontrolled severe infection.

  1. Known human immunodeficiency virus (HIV) infection.
  2. Known history of clinically significant liver disease, including viral hepatitis \[active HBV infection, i.e., positive HBV DNA (\>1×104 copies /mL or \>2000IU/ml) must be excluded for known hepatitis B virus (HBV) carriers.
  3. Known hepatitis C virus infection (HCV) and HCV RNA positive (\>1×103 copies /mL), or other hepatitis, cirrhosis\]

Where this trial is running

Jinhua, Zhejiang

• The Fourth Affiliated Hospital Zhejiang University School of Medicine — Jinhua, Zhejiang, China (RECRUITING)

Study contacts

• Principal investigator: Dezhi Li, MD&PhD — China, The Fourth Affiliated Hospital Zhejiang University School of Medicine
• Study coordinator: Dezhi Li, MD&PhD

Conditions: Colorectal Cancer Metastatic