Living donor liver transplant for patients with colorectal cancer spread to the liver
Liver Transplantation From Living Donors For Treatment Of Non-Resectable Colorectal Carcinoma Liver Metastases: A Registry Study
This study is trying to see how well living donor liver transplants work for people with colorectal cancer that has spread to the liver by collecting information on their survival and recovery.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 25 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | University of Rochester Academic / other |
| Locations | 1 site (Rochester, New York) |
| Trial ID | NCT05248581 on ClinicalTrials.gov |
What this trial studies
This study aims to establish a data registry that collects clinical, pathologic, and molecular data from patients with metastatic colorectal cancer who are undergoing living donor liver transplantation. The primary focus is on assessing overall survival and recurrence-free survival rates for these patients. By gathering comprehensive data, the study seeks to improve understanding of outcomes associated with this treatment approach. The observational nature of the study allows for real-world data collection without altering patient care.
Who should consider this trial
Good fit: Ideal candidates for this study are adults aged 18 and older with histologically confirmed colorectal cancer that is not amenable to curative surgical resection.
Not a fit: Patients who are not candidates for living donor liver transplantation or those unwilling to consent will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could provide valuable insights that improve treatment outcomes for patients with unresectable colorectal liver metastases.
How similar studies have performed: While the approach of using living donor liver transplantation for colorectal liver metastases is being explored, this specific observational study is novel in its focus on creating a comprehensive data registry.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age ≥ 18 * Non-amenable to curative hepatic resection as defined by FLR \<30% * Histologically confirmed adenocarcinoma of the colon or rectum * Candidate for LDLT for colorectal liver metastasis per the University of Rochester liver transplant program Exclusion Criteria: * Not a candidate of the LDLT liver transplant protocol for treatment of colorectal liver metastasis. * Unwilling to consent
Where this trial is running
Rochester, New York
- University of Rochester Medical Center — Rochester, New York, United States (Recruiting)
Study contacts
- Principal investigator: Roberto Hernandez-Alejandro, MD — University of Rochester
- Study coordinator: Roberto Hernandez-Alejandro, MD
- Email: roberto_hernandez@urmc.rochester.edu
- Phone: 585-275-5875
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.