Condition

Advanced Colorectal Cancer clinical trials and research

• 11Clinical trials
• 1NIH research projects
• 5Countries

Newest Advanced Colorectal Cancer clinical trials

All recruiting trials (11)

• SHR-A1811 plus chemotherapy and bevacizumab as first-line treatment for advanced colorectal cancer

  A first-line treatment test combines SHR-A1811 with chemotherapy and bevacizumab to see if it works better than standard therapy in adults with advanced colorectal cancer.

  Recruiting Phase 3 Suzhou Suncadia Biopharmaceuticals Co., Ltd. · Beijing, Beijing Municipality · NCT07676162

• Following therapy response with a blood test (liquid biopsy) in metastatic colorectal cancer

  This trial tests whether using a blood test that measures NPY-methylation ctDNA to guide treatment decisions helps people with unresectable metastatic colorectal cancer who are starting first-line therapy.

  Recruiting at 9 sites Phase 3 University Hospital, Antwerp · Mechelen, Antwerpen and 8 other locations · NCT07558083

• First-line treatment of advanced colorectal cancer using simultaneous levofolinate and 5‑FU infusion

  This trial will try combining simultaneous infusion of levofolinate (levozolinate) with 5‑FU as first-line chemotherapy for adults with unresectable or metastatic colorectal cancer.

  Recruiting Phase 2 Chinese PLA General Hospital · Beijing · NCT07391618

• CBI-1214 T-cell engager for advanced MSS/MSI-L colorectal cancer

  This trial will test whether the experimental T-cell engager CBI-1214 is safe, reaches appropriate blood levels, and can shrink tumors in people with advanced or metastatic MSS/MSI-L colorectal cancer who have had prior treatment.

  Recruiting at 10 sites Phase 1 Cartography Biosciences · Phoenix, Arizona and 9 other locations · NCT07321106

• Second-line therapy with Ongericimab and Toripalimab plus bevacizumab and chemotherapy in advanced MSS/pMMR colorectal cancer

  This study tests a second-line treatment that combines Ongericimab and Toripalimab with bevacizumab and chemotherapy for adults with advanced MSS/pMMR colorectal cancer who have progressed after first-line therapy.

  Recruiting Phase 2 Shanghai Pudong Hospital · Shanghai, Shanghai Municipality · NCT07106034

• JS207 with or without JS015 plus XELOX chemotherapy for advanced colorectal cancer

  This study will test whether adding the new drug JS207, alone or with JS015, to standard XELOX chemotherapy helps people with advanced MSS/pMMR colorectal cancer respond better or live longer.

  Recruiting at 2 sites Phase 2 Shanghai Junshi Bioscience Co., Ltd. · Beijing, Beijing Municipality and 1 other locations · NCT06885385

• Evaluating RBS2418 for advanced colorectal cancer

  This study is testing a new immune treatment called RBS2418 to see if it can help people with advanced colorectal cancer who haven't had success with other treatments.

  Recruiting at 8 sites Phase 2 Riboscience, LLC. · Newark, Delaware and 7 other locations · NCT06824064

• Evaluating PET/CT Imaging for Advanced Colorectal Cancer

  This study is testing if two types of PET/CT imaging can help doctors see how well conversion therapy is working for patients with advanced colorectal cancer and peritoneal metastasis.

  Recruiting Ruijin Hospital · Shanghai, Shanghai Municipality · NCT06601075

• TL938 plus trastuzumab for HER2-positive metastatic colorectal cancer

  This Phase 2 test checks whether combining oral TL938 with trastuzumab helps adults with HER2-positive, RAS wild-type metastatic or unresectable colorectal cancer that has progressed after standard chemotherapy.

  Recruiting Phase 2 Suzhou Teligene Ltd. · Beijing, Beijing Municipality · NCT06589830

• Using modified stem cells to treat advanced colorectal cancer

  This study is testing if specially modified stem cells from umbilical cords can help boost the immune system in people with advanced colorectal cancer who haven't responded to regular treatments.

  Recruiting Early Phase 1 Shanghai East Hospital · Shanghai, Shanghai Municipality · NCT06446050

• Combination treatment for advanced colorectal cancer

  This study is testing a new combination of three drugs to see if it can help people with advanced colorectal cancer that hasn't responded to other treatments.

  Recruiting Phase 2 M.D. Anderson Cancer Center · Houston, Texas · NCT06369259

NIH-funded research (1)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Systemic Targeted Alpha Therapy for Advanced Colorectal Cancer using Lead-203/Lead-212 PRIT

  A new therapy approach uses alpha-emitting radioisotopes paired for imaging and treatment to target colorectal cancer in patients.

  NIH research Weill Medical Coll of Cornell Univ · New York, United States · NIH-11433948

Related topics

Quick answers

How many Advanced Colorectal Cancer clinical trials are recruiting right now?

11, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 5 countries. The most sites are in China (7 trials), United States (3 trials), Puerto Rico (1 trial), Vietnam (1 trial), Belgium (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 6, Phase 3: 2, Early Phase 1: 1, Phase 1: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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