Understanding how autonomic dysfunction affects patients with heart failure and preserved ejection fraction.
Official title: Autonomic Dysfunction in Patients with HFpEF
Funded at University of Utah · NIH-11040309 · Data updated 2026-11-12
This study is looking at how problems with the nervous system might make it harder for people with heart failure and preserved ejection fraction (HFpEF) to exercise and breathe comfortably, and it aims to find out why these issues happen during physical activity.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Utah NIH-funded |
| Lab location | 1 site (Salt Lake City, United States) |
| Project start | March 1, 2023 |
| Project end | February 28, 2027 |
| Funding year | 2025 |
| Award (this year) | $615,718 |
| NIH project number | 5R01HL162856-03 |
| Project ID | NIH-11040309 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with heart failure with preserved ejection fraction who experience symptoms like shortness of breath and exercise intolerance.
✕Less likely to help
Patients with heart failure with reduced ejection fraction or those without heart failure may not benefit from this research.
What this research studies
This research investigates the role of autonomic dysfunction in patients suffering from heart failure with preserved ejection fraction (HFpEF). It focuses on how changes in the sympathetic nervous system may lead to exercise intolerance and dyspnea, which are common symptoms in these patients. By examining the mechanisms of blood flow regulation and vascular control, the study aims to uncover the underlying causes of these symptoms. Patients may undergo assessments to evaluate their cardiovascular responses during physical activities.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for patients with HFpEF, enhancing their quality of life and exercise capacity.
How similar studies have gone: Previous research has indicated that understanding autonomic dysfunction can lead to significant advancements in managing heart failure, suggesting that this approach may yield valuable insights.
Where this research is happening
-
University of Utah
Salt Lake City, United States Active
Researchers
- Principal investigator: Wray, D. Walter — University of Utah
- Study coordinator: Wray, D. Walter
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.