Understanding Autonomic System Changes After Severe Brain Injury
Official title: Impact of Autonomic Dysfunction on Multi-Organ Dysfunction following Severe TBI: The AUTO-BOOST Study
Funded at Duke University · NIH-11123126 · Data updated 2026-11-12
This research looks at how the body's automatic functions change after a severe brain injury and how these changes affect other organs.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Duke University NIH-funded |
| Lab location | 1 site (Durham, United States) |
| Project start | June 1, 2023 |
| Project end | May 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $599,123 |
| NIH project number | 5R01NS130832-03 |
| Project ID | NIH-11123126 on NIH RePORTER |
Who could benefit from this research
✓Could help
This research focuses on understanding data from adults aged 21 and older who have experienced severe traumatic brain injury.
✕Less likely to help
Patients with mild or moderate brain injuries, or those without autonomic dysfunction, may not directly benefit from this specific research.
What this research studies
Severe traumatic brain injury (TBI) can lead to problems in many organs beyond the brain, which can make recovery harder. We know that the autonomic nervous system, which controls automatic body functions like heart rate and breathing, often doesn't work right after a severe TBI. This project uses detailed information from a large clinical trial to understand exactly how these autonomic changes happen and how they might lead to other organ problems. By understanding this better, doctors hope to find new ways to help patients recover more fully.
Why it matters
Potential benefit: If successful, this work could lead to new treatments that improve recovery and reduce complications for patients after severe traumatic brain injury.
How similar studies have gone: Prior research has shown a link between early autonomic nervous system dysfunction and complications after severe TBI, suggesting this approach builds on existing knowledge.
Where this research is happening
-
Duke University
Durham, United States Active
Researchers
- Principal investigator: Krishnamoorthy, Vijay — Duke University
- Study coordinator: Krishnamoorthy, Vijay
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.