See if small fiber neuropathy is common in people with primary Sjögren’s syndrome

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This prospective study will measure how often small fiber neuropathy occurs in patients with primary Sjögren’s syndrome and describe the associated clinical features and immune profiles. The researchers will use Sudoscan, a non-invasive skin conductance test, to screen for SFN and explore correlations with autoimmune markers. Participants will be adults with confirmed pSS, and several exclusion criteria are in place to minimize confounding conditions that cause SFN. The study aims to improve early detection and inform how SFN relates to pSS pathology. Results could help guide patient management and future research directions.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age ≥ 18 years
* Primary Sjögren's syndrome confirmed according to ACR/EULAR criteria 2016
* Body Mass Index between 18 and 35 kg/m²

Exclusion Criteria:

* Secondary or unconfirmed Sjögren's syndrome,
* Age \< 18 years, Use of medications that could interfere with Sudoscan results and which could not be discontinued before inclusion,
* Other conditions that may cause small fiber neuropathy,
* type 2 diabetes,
* excessive alcohol consumption,
* sarcoidosis
* obesity

Where it's running

• CHU Amiens
  Amiens, France Recruiting

Study contacts

• Study coordinator: Valéry SALLE, MD
• Email: salle.valery@chu-amiens.fr
• Phone: 33+3 22 66 82 30

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.