Polish registry of heart nerve–targeting treatments (cardioneuroablation and cardioneuromodulation)

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

POL-CA is a multicenter observational registry combining retrospective and prospective data on adults who have undergone or will undergo procedures that modify cardiac autonomic innervation, such as cardioneuroablation, sinoatrial-node-sparing hybrid ablation, and cardiac sympathetic denervation. The registry aims to enroll at least 1,000 participants across three age groups and to standardize data collection with a common POL-CA questionnaire and methodology. Data collected include clinical history, procedural details, perioperative and long-term complications, and patient-reported outcomes using EQ-5D, SF-36, VASIS, and MALMO scales. The goal is to provide a multicenter summary of patient characteristics, treatment patterns, and real-world outcomes for a spectrum of autonomic cardiac disorders.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age ≥ 18 years
* Diagnosis of at least one of the following conditions:

  * Inappropriate sinus tachycardia (IST)
  * Postural orthostatic tachycardia syndrome (POTS)
  * Vasovagal syncope (VVS)
  * Cardioinhibitory carotid sinus syndrome (CSS)
  * Symptomatic sinus bradycardia or functional AV block
  * Orthostatic hypotension (OH)
* History of recurrent autonomic symptoms (e.g., syncope, bradycardia, palpitations, orthostatic intolerance)
* Undergoing or previously underwent interventional treatment affecting cardiac autonomic innervation (e.g., cardioneuroablation, SN-sparing ablation, cardiac sympathetic denervation)
* Provided written informed consent (for prospective arm)

Exclusion Criteria:

* Structural heart disease requiring surgical intervention
* Permanent pacemaker or ICD implanted prior to enrollment
* Inability to complete follow-up assessments or questionnaires
* Severe psychiatric comorbidities impairing participation
* Participation in another interventional clinical trial

Where it's running

• SabaMed
  Rzeszów, Poland Recruiting

Study contacts

• Principal investigator: Sebastian Stec, Prof., MD, PhD — SABAMED Medical Center Ltd.
• Study coordinator: Sebastian Stec, Prof., MD, PhD
• Email: smstec@wp.pl
• Phone: +48600298022

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.