Impact of Autonomic Dysfunction on Multi-Organ Problems after Severe TBI
Official title: Impact of Autonomic Dysfunction on Multi-Organ Dysfunction following Severe TBI: The AUTO-BOOST Study
Funded at Duke University · NIH-11365847 · Data updated 2026-11-12
A big study at Duke looks at how early problems with the automatic nervous system after a severe brain injury relate to organ issues and brain energy problems, aiming to guide new therapies for better recovery.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Duke University NIH-funded |
| Lab location | 1 site (Durham, United States) |
| Project start | June 1, 2023 |
| Project end | May 31, 2028 |
| Funding year | 2026 |
| Award (this year) | $587,250 |
| NIH project number | 5R01NS130832-04 |
| Project ID | NIH-11365847 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults with a history of severe traumatic brain injury who were enrolled in the BOOST-3 trial or who meet its related criteria.
✕Less likely to help
Patients not experiencing autonomic dysfunction or not connected to the BOOST-3 data may have limited immediate applicability.
What this research studies
This project follows people who have suffered a severe traumatic brain injury to understand how early autonomic dysfunction affects both brain energy crisis and damage to other organs. Using detailed waveform data from a large prior trial (BOOST-3), researchers will map how autonomic issues emerge and how they relate to cerebral metabolic crises and multi-organ dysfunction. The goal is to identify patterns that can inform timing and targets for treatments to improve outcomes after TBI. Results could lead to therapies that reduce secondary brain injury and organ injury in the year after TBI.
Why it matters
Potential benefit: If successful, the study could lead to therapies that lessen brain and organ injury after severe TBI and improve long-term recovery.
How similar studies have gone: Prior work has linked autonomic dysfunction to worse outcomes in TBI, but this project adds granular waveform analysis to connect early dysfunction with later brain and organ injury.
Where this research is happening
-
Duke University
Durham, United States Active
Researchers
- Principal investigator: Krishnamoorthy, Vijay — Duke University
- Study coordinator: Krishnamoorthy, Vijay
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.