Decoding neutrophil membranes in antiphospholipid syndrome
Funded at University of Michigan at Ann Arbor · NIH-11271719 · Data updated 2026-11-12
A patient-facing look at a study that aims to understand how neutrophils and cell membranes contribute to blood clots in antiphospholipid syndrome and how this could lead to new ways to diagnose and treat the condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project start | September 1, 2026 |
| Project end | May 31, 2030 |
| Funding year | 2026 |
| Award (this year) | $529,957 |
| NIH project number | 1R01HL183390-01 |
| Project ID | NIH-11271719 on NIH RePORTER |
Who could benefit from this research
✓Could help
People with antiphospholipid syndrome who may participate in future diagnostics or treatment-related studies and samples.
✕Less likely to help
Some participants may not directly benefit if they are not recipients of any experimental diagnostic or therapeutic approach studied.
What this research studies
This project focuses on antiphospholipid syndrome (APS), a condition that increases the risk of blood clots. Researchers will explore how cell membranes and immune factors interact in APS to cause clotting, with a spotlight on neutrophils and membrane proteins. By studying the membrane changes and inflammatory signals in APS, the team hopes to identify new targets for diagnosis, subtyping, and therapy. The work includes experiments in human cells and animal models to understand mechanisms that drive thrombosis in APS.
Why it matters
Potential benefit: If successful, the research could lead to better how APS is diagnosed and treated, potentially reducing clot risk for patients.
How similar studies have gone: Preclinical studies have shown that neutrophil mechanisms and membrane processes are involved in APS, supporting the feasibility of this approach.
Where this research is happening
-
University of Michigan at Ann Arbor
Ann Arbor, United States Active
Researchers
- Principal investigator: Knight, Jason — University of Michigan at Ann Arbor
- Study coordinator: Knight, Jason
Related research
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.