Impact of Alcohol and Drugs on Immune Function in Critically Ill Patients with Lung Issues

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to investigate the effects of alcohol and drug use on immune function in critically ill patients suffering from respiratory failure and lung infections. By analyzing the health outcomes of patients admitted to the ICU with these conditions, the study seeks to understand how substance use may influence the severity of lung infections and overall recovery. Participants will be monitored for their alcohol, tobacco, and drug use to identify potential correlations with their respiratory health. The findings could provide insights into the risks associated with substance use in critically ill patients.

Why it matters

Who can join: the full rules

Inclusion criteria:

* Specific Aim 1: Adult medical ICU patients admitted to the University of Colorado Hospital for a primary respiratory problem, and who are expected to require ICU care ≥48 hrs
* Specific Aim 2: (1) Adult medical ICU patients with respiratory failure (due to underlying lung pathology) and who require endotracheal intubation and mechanical ventilation. (2) Adult medical and other ICU patients with respiratory failure, not related to a lung condition, and who require endotracheal intubation and mechanical ventilation. (3) Adult ICU patients previously admitted to the University of Colorado Hospital for a primary respiratory problem, and who required care ≥48 hrs.

Exclusion criteria, Specific Aim 1 and 2:

* Patients who are expected to require ICU care \<48 hrs
* Patients admitted to the ICU who are not ICU status (being housed for space issues)
* Patient is unlikely to survive 48 hours
* Patient is on comfort care (hospice measures)
* Patients less than 18 or greater than 90 years of age
* Patient is a prisoner
* ICU attending declines enrollment of patient
* Patients who are pregnant
* Patients who have significant anemia, defined as Hgb\<8% or Hct\<24%, or who have evidence of active bleeding.

For bronchoscopy portion of Specific Aim 2.

* Patients who are on either a fraction of inspired oxygen inspired oxygen fraction (FiO2)\>80% or positive end expiratory pressure (PEEP) \>10 cm H20
* Patients with platelets less than 30,000(chronically)
* Patients who are expected to undergo a spontaneous breathing trial within the next 4 hours
* Patients with an order or plan to extubate in the next 4 hours
* Patients who have an endotracheal tube (ETT) \<7.5 F
* Patients who are currently dangerously agitated
* Pregnant women

Exclusion criteria (outpatients ONLY for SA2 (3)):

1. Patients who required ICU care \<48 hrs
2. Patients less than 18 or greater than 90 years of age
3. Patient is a prisoner
4. Patients who are pregnant
5. Residency \> 40 miles from UCH clinics
6. non-English or non-Spanish speaking
7. Inability to perform study procedures (i.e. physical disability)
8. unable to perform pulmonary function testing
9. diagnosis of chronic pulmonary disease (e.g. COPD)
10. diagnosis of chronic neurodegenerative disease or severe dementia
11. history of anoxic or traumatic brain injury
12. prior ICU hospitalization at a non-UCH facility.

Where it's running

• University of Colorado Hospital
  Aurora, Colorado, United States Recruiting

Study contacts

• Principal investigator: Ellen L Burnham, MD — University of Colorado, Denver
• Study coordinator: Ellen L Burnham, MD
• Email: ellen.burnham@ucdenver.edu
• Phone: 303-724-6078

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.