How brain cells respond to alcohol abuse
Official title: The Functional Implications of Astrocytic GPCR-signaling on Alcohol Abuse
Funded at North Carolina Central University · NIH-10883676 · Data updated 2026-11-12
This study looks at how binge drinking affects certain brain cells called astrocytes and how these changes might influence drinking habits, with the goal of finding new ways to help people who struggle with alcohol use.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | North Carolina Central University NIH-funded |
| Lab location | 1 site (Durham, United States) |
| Project start | August 20, 2021 |
| Project end | July 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $370,000 |
| NIH project number | 5SC1GM139696-04 |
| Project ID | NIH-10883676 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults over the age of 21 who engage in binge drinking behaviors.
✕Less likely to help
Patients who do not consume alcohol or are not involved in binge drinking may not benefit from this research.
What this research studies
This research investigates how specific brain cells, called astrocytes, are affected by binge drinking and how these changes may influence alcohol-related behaviors. By examining the neurobiological mechanisms involved, the study aims to understand the role of astrocytic signaling in alcohol consumption and dependence. The research will involve analyzing the activation and expression patterns of astrocytes in response to alcohol, as well as the long-term effects of repeated binge drinking on these cells. This could lead to new therapeutic strategies for addressing alcohol misuse.
Why it matters
Potential benefit: If successful, this research could lead to innovative treatments for individuals struggling with alcohol dependence and binge drinking.
How similar studies have gone: Previous research has shown promising results in understanding the neuroimmune system's role in alcohol abuse, suggesting that this approach could yield valuable insights.
Where this research is happening
-
North Carolina Central University
Durham, United States Active
Researchers
- Principal investigator: Marshall, Simon Alexander — North Carolina Central University
- Study coordinator: Marshall, Simon Alexander
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.