Sponsor or institution
Clinical trials and research at Wm S. Middleton Memorial Veterans Hosp
As of November 12, 2026, Find a Trial lists 42 NIH-funded research projects at this institution. Every study is explained in plain English. Data from ClinicalTrials.gov and NIH RePORTER, updated November 12, 2026.
- 42NIH research projects
NIH-funded research (newest 40 of 42)
Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.
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New microfluidic platform to test prostate cancer drugs using patient tumor cells
A new microfluidic, open platform uses patient-derived prostate cancer cells to create multi-culture tumor models that could better predict whether a treatment will work for Veterans.
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Injecting immune-boosting medicine into melanoma tumors to help the immune system reject them
This gives an immune-boosting drug directly into melanoma tumors in pet dogs to help their T cells find and destroy the cancer.
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Preventing anal cancer in people living with HIV
A topical form of HIV protease inhibitors is being tried to clear precancerous anal changes in people living with HIV.
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SIRT6 and melanoma growth and spread
Researchers are seeing if blocking a protein called SIRT6 can help stop melanoma from growing and spreading in people with melanoma.
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Vitamin C to protect the brain after a traumatic brain injury
This project is testing whether giving vitamin C after a traumatic brain injury can protect the brain and help adults recover.
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Investigating melanoma development and potential treatments
This study is looking at how melanoma grows and changes, with the goal of finding ways to better predict outcomes and develop new treatments for people with early-stage melanoma, including Veterans and others.
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G‑proteins' role in insulin‑producing beta cell health in type 2 diabetes
This project looks at how a signaling protein called Gαz affects insulin-producing beta cells in people with type 2 diabetes to find ways to keep those cells working longer.
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Measuring swallowing pressures to improve treatment outcomes for difficulty swallowing
This study is looking at a new way to measure how well people with swallowing difficulties can swallow, using a special test, to help doctors understand how treatments are working and improve care for those with oropharyngeal dysphagia.
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Investigating the role of a protein in melanoma development and progression
This study is looking at how a protein called SIRT6 affects the growth and spread of melanoma, a serious skin cancer, to find new ways to treat it better for patients.
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Weight loss with support from partners and housemates
This program helps Veterans and someone they live with learn skills to keep weight off long-term.
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Gut microbiome, fiber, and short-chain fatty acids in Veterans with Gulf War Illness
This project tests whether Veterans with Gulf War Illness who have gut problems have lower levels of helpful gut bacteria and short-chain fatty acids, and whether eating more fiber relates to fewer digestive symptoms.
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AI tool to predict chemotherapy response for brain tumors
This project will build an AI tool to help doctors predict which people with glioblastoma are unlikely to benefit from chemotherapy.
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Investigating chronic multi-symptom illnesses in veterans
This study is looking into the ongoing health issues that many Gulf War veterans face, like fatigue, pain, and trouble thinking, to find out what might be causing these problems and help improve their well-being.
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Finding better ways to help veterans who smoke but don't want to quit
This study is looking for ways to help veterans who smoke but aren't ready to quit yet, by offering them support and encouragement to eventually reduce or stop smoking.
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Using living electrodes to improve hearing rehabilitation.
This study is exploring a new way to help people with severe hearing loss by using special living materials that can improve how sound is processed in the brain, which could lead to better hearing than what current cochlear implants offer.
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Improving cancer prevention and treatment for Veterans
This study is looking into how cancer develops and how we can better prevent and treat it, especially for Veterans, by focusing on skin and prostate cancers that they often face, including melanoma, which is linked to sun exposure during service.
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Finding therapies to prevent brain damage and promote recovery after brain injuries.
This study is looking at new treatments to help people recover better after a traumatic brain injury or stroke by testing a mix of antioxidants that could protect the brain and improve movement, thinking, and mood.
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A new microscale lab platform that uses patient prostate tumor cells to test treatments
This project uses a tiny lab system that grows patient prostate tumor cells to help find treatments more likely to work for men with prostate cancer.
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Targeting two key proteins to improve melanoma treatment
This study is looking at how blocking two specific proteins can help fight melanoma and make treatments work better, so patients can have more effective options for managing their condition.
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Teaching Veterans about obesity treatment options
This study is all about helping Veterans learn about different ways to treat obesity, like programs, medications, and surgery, using telemedicine so they can easily access the information and support they need to get started on their journey to better health.
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Examining infection prevention practices in healthcare during the COVID-19 pandemic
This study looks at how the COVID-19 pandemic changed the way hospitals and clinics prevent infections, like making sure hands are clean and surfaces are sanitized, and it aims to find out what worked well and what didn't so that we can make healthcare safer for everyone, especially veterans.
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Understanding how cell movement affects melanoma spread
This study is looking at how a specific pathway in our cells might help melanoma, a serious skin cancer that often affects military personnel, spread to other parts of the body, with the hope of finding new ways to slow down the cancer and improve treatment options for patients.
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Understanding how patient-derived cancer organoids respond to treatment in cholangiocarcinoma
This study is looking at ways to create mini versions of your cancer to see how different treatments work, with the hope of finding better options for people with bile duct cancer.
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Investigating new ways to prevent and treat diabetes in veterans
This study is looking at how the pancreas makes insulin and what goes wrong in type 2 diabetes, especially in veterans, to find better ways to diagnose and treat the condition.
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Understanding how mTOR signaling affects post-traumatic osteoarthritis
This NIH grant investigates how two mTOR signaling pathways influence joint damage and pain after injury, with a focus on cartilage health and potential gender differences.
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Vitamin C may help protect the brain after traumatic injuries.
This study is looking at whether Vitamin C can help protect the brain and improve recovery for people who have had a traumatic brain injury, by reducing damage and boosting brain function.
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Helping Veterans lose weight with support from loved ones
This study is looking at how having a partner or close friend join Veterans in their weight loss journey can help them stick to healthy habits and lose weight for the long haul, while teaching everyone involved some great ways to support each other.
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Detecting and characterizing melanoma cells in the bloodstream
This study is looking at ways to find tiny cancer cells in the blood of people with melanoma, which can help doctors understand how the disease is spreading and improve monitoring, so patients can get the right care sooner.
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Investigating the long-term effects of COVID-19 on Veterans' health
This study is looking at how Veterans feel after recovering from COVID-19, especially any ongoing symptoms like pain, tiredness, and brain fog, and it wants to see how exercise might help improve these issues by exploring changes in their gut health and brain inflammation.
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Understanding how certain molecules affect insulin-producing cells in diabetes
This study is looking at how a certain molecule affects the insulin-making cells in the pancreas, which is important for people with type 2 diabetes, and aims to find new ways to help these cells work better and stay healthy, especially for veterans.
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Investigating a microRNA that may protect the brain after a stroke
This study is looking at how a tiny molecule called miR-21 might help protect the brain and improve recovery after a stroke, using mice to see if boosting miR-21 levels can reduce brain damage and help with movement.
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Preventing anal cancer in people living with HIV
This study is looking for better ways to prevent anal cancer in people with HIV by testing a new treatment for precancerous conditions, hoping to find options that work well and have fewer side effects.
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Understanding how to improve insulin secretion in diabetes
This study is looking at how a certain enzyme can help boost insulin production in the pancreas for veterans with type 2 diabetes, especially older adults and those dealing with obesity-related diabetes, to see if special compounds can make this process better.
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Investigating how a specific protein variant protects the heart during injury.
This study is looking at a special protein that might help protect heart cells when blood flow is low, which could lead to better treatments for heart conditions in the future.
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Enhancing mental health support for veterans with dementia through caregiver training
This study is all about helping aging veterans with dementia by training healthcare providers to better support their family caregivers, making it easier for them to access mental health services and improve the veterans' overall well-being.
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New cell culture platform for developing prostate cancer treatments
This study is working to find better treatments for prostate cancer, especially for Veterans, by growing tumor models from their own cells to see how well new therapies might work for them.
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How a hormone may help protect insulin-producing cells in diabetes
This study is looking at how a hormone called cholecystokinin (CCK) might help protect the insulin-making cells in your pancreas from damage, especially for people with diabetes, like many Veterans, by figuring out how it works and finding new ways to keep those cells healthy.
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Understanding how arterial stiffness affects blood pressure management in older veterans
This study is looking at how stiff arteries affect blood pressure in older veterans with high blood pressure, and it aims to find better ways to treat them by using simple tests and genetic information to personalize their care.
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Using artificial intelligence to improve chemotherapy decisions for brain tumor patients
This study is testing a new AI system that helps doctors figure out which glioblastoma patients, especially veterans, might not benefit from standard chemotherapy, so they can find better treatment options and avoid unnecessary costs and procedures.
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Investigating the gut microbiome's role in gastrointestinal issues among Gulf War veterans
This study is looking at how the bacteria in your gut might influence stomach and liver problems in veterans with Gulf War Illness, and it hopes to find ways to improve your gut health and reduce symptoms by examining your diet and gut bacteria.
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